TY - JOUR
T1 - Decrease in all-cause 30-day mortality after bacteraemia over a 15-year period
T2 - A population-based cohort study in Denmark in 2000–2014
AU - Holm, Mona Katrine Alberthe
AU - Jansåker, Filip
AU - Gradel, Kim Oren
AU - Nielsen, Rikke Thoft
AU - Østergaard Andersen, Christian
AU - Jarløv, Jens Otto
AU - Schønheyder, Henrik Carl
AU - Knudsen, Jenny Dahl
N1 - Funding Information:
This study was conducted as part of our routine work. No author received research funding. M.K.A.H. received a 5000 SEK young researchers travel grant from the SSAC Foundation to participate in the 36th annual NSCMID meeting to present a poster with preliminary results. The SSAC Foundation had no impact on study design, collection, interpretation of the data, or publication.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/6/2
Y1 - 2021/6/2
N2 - Introduction: Bacteraemia is a frequent infectious condition that strongly affects morbidity and mortality. The incidence is increasing worldwide. This study explores all-cause 30-day mortality after bacteraemia in two out of Denmark’s five healthcare regions with approximately 2.4 million inhabitants. Methods: Clinically significant bacteraemia episodes (n = 55,257) were identified from a geographically well-defined background population between 2000 and 2014, drawing on population-based data regarding bacterial species and vital status. All-cause 30-day mortality was assessed in relation to bacteraemia episodes, number of patients with analysed blood cultures and the background population. Results: We observed a decreasing trend of all-cause 30-day mortality between 2000 and 2014, both in relation to the number of bacteraemia episodes and the background population. Mortality decreased from 22.7% of the bacteraemia episodes in 2000 to 17.4% in 2014 (annual IRR [95% CI]: 0.983 [0.979–0.987]). In relation to the background population, there were 41 deaths per 100,000 inhabitants in 2000, decreasing to 39 in 2014 (annual IRR [95% CI]: 0.988 [0.982–0.993]). Numbers of inhabitants, bacteraemia episodes, and analysed persons having BCs increased during the period. Conclusions: All-cause 30-day mortality in patients with bacteraemia decreased significantly over a 15-year period.
AB - Introduction: Bacteraemia is a frequent infectious condition that strongly affects morbidity and mortality. The incidence is increasing worldwide. This study explores all-cause 30-day mortality after bacteraemia in two out of Denmark’s five healthcare regions with approximately 2.4 million inhabitants. Methods: Clinically significant bacteraemia episodes (n = 55,257) were identified from a geographically well-defined background population between 2000 and 2014, drawing on population-based data regarding bacterial species and vital status. All-cause 30-day mortality was assessed in relation to bacteraemia episodes, number of patients with analysed blood cultures and the background population. Results: We observed a decreasing trend of all-cause 30-day mortality between 2000 and 2014, both in relation to the number of bacteraemia episodes and the background population. Mortality decreased from 22.7% of the bacteraemia episodes in 2000 to 17.4% in 2014 (annual IRR [95% CI]: 0.983 [0.979–0.987]). In relation to the background population, there were 41 deaths per 100,000 inhabitants in 2000, decreasing to 39 in 2014 (annual IRR [95% CI]: 0.988 [0.982–0.993]). Numbers of inhabitants, bacteraemia episodes, and analysed persons having BCs increased during the period. Conclusions: All-cause 30-day mortality in patients with bacteraemia decreased significantly over a 15-year period.
KW - Bacteremia/epidemiology
KW - Cohort Studies
KW - Denmark/epidemiology
KW - Humans
KW - Incidence
KW - Morbidity
KW - epidemiology
KW - bacteraemia
KW - population-based study
KW - mortality
KW - bloodstream infection
UR - http://www.scopus.com/inward/record.url?scp=85107014372&partnerID=8YFLogxK
U2 - 10.3390/ijerph18115982
DO - 10.3390/ijerph18115982
M3 - Journal article
C2 - 34199587
AN - SCOPUS:85107014372
SN - 1661-7827
VL - 18
SP - 1
EP - 12
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
IS - 11
M1 - 5982
ER -