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Region Hovedstaden - en del af Københavns Universitetshospital
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Dangers of hyperoxia

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

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  • Mervyn Singer
  • Paul J Young
  • John G Laffey
  • Pierre Asfar
  • Fabio Silvio Taccone
  • Markus B Skrifvars
  • Christian S Meyhoff
  • Peter Radermacher
Vis graf over relationer

Oxygen (O2) toxicity remains a concern, particularly to the lung. This is mainly related to excessive production of reactive oxygen species (ROS). Supplemental O2, i.e. inspiratory O2 concentrations (FIO2) > 0.21 may cause hyperoxaemia (i.e. arterial (a) PO2 > 100 mmHg) and, subsequently, hyperoxia (increased tissue O2 concentration), thereby enhancing ROS formation. Here, we review the pathophysiology of O2 toxicity and the potential harms of supplemental O2 in various ICU conditions. The current evidence base suggests that PaO2 > 300 mmHg (40 kPa) should be avoided, but it remains uncertain whether there is an "optimal level" which may vary for given clinical conditions. Since even moderately supra-physiological PaO2 may be associated with deleterious side effects, it seems advisable at present to titrate O2 to maintain PaO2 within the normal range, avoiding both hypoxaemia and excess hyperoxaemia.

OriginalsprogEngelsk
Artikelnummer440
TidsskriftCritical care (London, England)
Vol/bind25
Udgave nummer1
Sider (fra-til)440
ISSN1466-609X
DOI
StatusUdgivet - 19 dec. 2021

Bibliografisk note

© 2021. The Author(s).

ID: 70610850