Abstract
Cytoplasmic inflammasomes are formed through activation of pattern recognition receptors (PRR) of the innate immune system. Endogenous and exogenous danger signals, e.g. DNA- and RNA-fragments, urate- and cholesterol crystals, silica and asbestos, ß-amyloid, UV-light and skin irritants, may induce NOD-like receptor protein (NLRP)3 inflammasomes. These inflammasomes govern the induction of proinflammatory cytokines such as IL-1ß, IL-18 and IL-33. PRR and inflammasome dysfunctions may underly immunoinflammatory diseases such as gout and other arthritides, type 1 diabetes and arteriosclerosis.
| Bidragets oversatte titel | Danger signals and inflammasomes in autoinflammatory and autoimmune diseases |
|---|---|
| Originalsprog | Dansk |
| Tidsskrift | Ugeskrift for Laeger |
| Vol/bind | 173 |
| Udgave nummer | 38 |
| Sider (fra-til) | 2340-3 |
| Antal sider | 4 |
| ISSN | 0041-5782 |
| Status | Udgivet - 2011 |
Emneord
- Arteriosclerosis
- Arthritis
- Autoimmune Diseases
- Cytokines
- Diabetes Mellitus, Type 1
- Hereditary Autoinflammatory Diseases
- Humans
- Immunity, Innate
- Inflammasomes
- Inflammation
- Nod Signaling Adaptor Proteins
- Receptors, Pattern Recognition
- Receptors, Tumor Necrosis Factor
- Toll-Like Receptors