Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Daily mobility patterns in patients with bipolar disorder and healthy individuals

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Primary prevention of depression: An umbrella review of controlled interventions

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Stress management versus cognitive restructuring in trauma-affected refugees - A follow-up study on a pragmatic randomised trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Alzheimer's disease related biomarkers in bipolar disorder - A longitudinal one-year case-control study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Reduced prefrontal cortex response to own vs. unknown emotional infant faces in mothers with bipolar disorder

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Incomplete systematic review and meta-analysis on statin use and depression risk - A commentary

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

Vis graf over relationer

BACKGROUND: Alterations in energy and activity in bipolar disorder (BD) differ between affective states and compared with healthy control individuals (HC). Measurements of activity could discriminate between BD and HC and in the monitoring of affective states within BD. The aims were to investigate differences in 1) passively collected smartphone-based location data (location data) between BD and HC, and 2) location data in BD between affective states.

METHODS: Daily, patients with BD and HC completed smartphone-based self-assessments of mood for up to nine months. Location data reflecting mobility patterns, routine and location entropy was collected daily. A total of 46 patients with BD and 31 HC providing daily data was included.

RESULTS: A total of 4,859 observations of smartphone-based self-assessments of mood and mobility patterns were available from patients with BD and 1,747 observations from HC. Patients with BD had lower location entropy compared with HC (B= -0.14, 95% CI= -0.24; -0.034, p=0.009). Patients with BD during a depressive state were less mobile compared with a euthymic state. Patients with BD during an affective state had lower location entropy compared with a euthymic state (p<0.0001). The AUC of combined location data was rather high in classifying patients with BD compared with HC (AUC: 0.83).

LIMITATIONS: Individuals willing to use smartphones for daily self-monitoring may represent a more motivated group.

CONCLUSION: Alterations in location data reflecting mobility patterns may be a promising measure of illness and illness activity in patients with BD and may be used to monitor the effects of treatments.

OriginalsprogEngelsk
TidsskriftJournal of Affective Disorders
Vol/bind278
Sider (fra-til)413-422
Antal sider10
ISSN0165-0327
DOI
StatusUdgivet - 1 jan. 2021

Bibliografisk note

Copyright © 2020. Published by Elsevier B.V.

ID: 61340165