D-dimer as a potential blood biomarker for disease activity and treatment response in chronic urticaria: a focused review

Abstract

Chronic urticaria is an itchy skin disease, which is treated with antihistamines; however, a large group of patients are unresponsive to antihistamines alone and are thus treated with omalizumab, although a small fraction of these patients have particularly recalcitrant disease. Currently, there are no reliable biomarkers available to assess disease activity/severity and treatment response in chronic urticaria patients. However, it has been reported that high levels of D-dimer are observed during disease activity and are significantly reduced during periods of remission. We present a focused overview of studies investigating plasma D-dimer level as a biomarker for disease activity and treatment response in patients with chronic urticaria.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Dermatology
Vol/bind28
Udgave nummer6
Sider (fra-til)731-735
Antal sider5
ISSN1167-1122
DOI
StatusUdgivet - 1 dec. 2018

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