TY - JOUR
T1 - D-dimer as a potential blood biomarker for disease activity and treatment response in chronic urticaria
T2 - a focused review
AU - Ghazanfar, Misbah Noshela
AU - Thomsen, Simon Francis
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Chronic urticaria is an itchy skin disease, which is treated with antihistamines; however, a large group of patients are unresponsive to antihistamines alone and are thus treated with omalizumab, although a small fraction of these patients have particularly recalcitrant disease. Currently, there are no reliable biomarkers available to assess disease activity/severity and treatment response in chronic urticaria patients. However, it has been reported that high levels of D-dimer are observed during disease activity and are significantly reduced during periods of remission. We present a focused overview of studies investigating plasma D-dimer level as a biomarker for disease activity and treatment response in patients with chronic urticaria.
AB - Chronic urticaria is an itchy skin disease, which is treated with antihistamines; however, a large group of patients are unresponsive to antihistamines alone and are thus treated with omalizumab, although a small fraction of these patients have particularly recalcitrant disease. Currently, there are no reliable biomarkers available to assess disease activity/severity and treatment response in chronic urticaria patients. However, it has been reported that high levels of D-dimer are observed during disease activity and are significantly reduced during periods of remission. We present a focused overview of studies investigating plasma D-dimer level as a biomarker for disease activity and treatment response in patients with chronic urticaria.
U2 - 10.1684/ejd.2018.3443
DO - 10.1684/ejd.2018.3443
M3 - Journal article
C2 - 30530404
SN - 1167-1122
VL - 28
SP - 731
EP - 735
JO - European Journal of Dermatology
JF - European Journal of Dermatology
IS - 6
ER -