Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

CytoTrack Analysis Reveals Low Presence of Circulating Tumor Cells in the Perioperative Period in Patients with Non-metastatic Colorectal Cancer

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Neoadjuvant Chemotherapy Reduces the Treatment-free Interval After First-line Treatment in Patients With Advanced Ovarian Cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Long-term Survival After Surgical Treatment of Spinal Metastasis - The Predictive Role of Sex

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Improving Photoprotection and Implications for 25(OH)D Formation

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Lifetime UVR Dose and Skin Cancer Risk, Determined by Their Common Relation to Solar Lentigines

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Feasibility of single-cell analysis of model cancer and foetal cells in blood after isolation by cell picking

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Triage for selection to colonoscopy?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Clean Colorectum at Diagnostic Colonoscopy: Subsequent Detection of Extracolonic Malignancies by Plasma Protein Biomarkers?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Detection of colorectal neoplasia: Combination of eight blood-based, cancer-associated protein biomarkers

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND/AIM: Detection of circulating tumor cells in the perioperative period predicts poor prognosis in patients with colorectal cancer. There is only one Food and Drug Administration-approved method for such detection, CellSearch, for which results have been inconsistent. A new immunological method, CytoTrack, has shown promising results in patients with breast cancer. The aim of this study was to evaluate detection of circulating tumor cells in the peripheral blood of patients with non-metastatic colorectal cancer with CytoTrack, and investigate if there is a correlation between presence of circulating tumor cells and Union for International Cancer Control (UICC) stage and if surgery itself results in the release of circulating tumor cells.

PATIENTS AND METHODS: A prospective study was conducted including patients with colorectal cancer UICC stage I-III who underwent minimally-invasive surgery. Patients with previous cancer diagnosis or neoadjuvant chemo/ radiotherapy were excluded. Blood samples were collected from all included patients one day prior to and one day after surgery. Detection of circulating tumor cells was performed using CytoTrack.

RESULTS: A total of 20 patients were consecutively included. Circulating tumor cells were detected in one preoperative sample and two postoperative samples.

CONCLUSION: The presence of circulating tumor cells is rare in patients with non-metastatic colorectal cancer and the new method we used, CytoTrack, was only able to detect circulating tumor cells in three out of 40 blood samples. More specific antibodies are needed to identify circulating tumor cells in these patients.

OriginalsprogEngelsk
TidsskriftAnticancer Research
Vol/bind37
Udgave nummer6
Sider (fra-til)3099-3103
Antal sider5
ISSN0250-7005
DOI
StatusUdgivet - 2017

ID: 50696587