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Cytoplasmic mRNPs revisited: Singletons and condensates

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DOI

  1. RNA assemblages orchestrate complex cellular processes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Cytoplasmic messenger ribonucleoprotein particles (mRNPs) represent the cellular transcriptome, and recent data have challenged our current understanding of their architecture, transport, and complexity before translation. Pre-translational mRNPs are composed of a single transcript, whereas P-bodies and stress granules are condensates. Both pre-translational mRNPs and actively translating mRNPs seem to adopt a linear rather than a closed-loop configuration. Moreover, assembly of pre-translational mRNPs in physical RNA regulons is an unlikely event, and co-regulated translation may occur locally following extracellular cues. We envisage a stochastic mRNP transport mechanism where translational repression of single mRNPs-in combination with microtubule-mediated cytoplasmic streaming and docking events-are prerequisites for local translation, rather than direct transport.

OriginalsprogEngelsk
TidsskriftBioEssays
Vol/bind42
Udgave nummer12
Sider (fra-til)e2000097
ISSN0265-9247
DOI
StatusUdgivet - dec. 2020

Bibliografisk note

© The Authors. BioEssays published by Wiley Periodicals LLC.

ID: 62075248