Cytokines and growth factors modify the upregulation of contractile endothelin ET(A) and ET(B) receptors in rat cerebral arteries after organ culture

H Ahnstedt; E Stenman; L Cao; M Henriksson; L Edvinsson

doi:10.1111/j.1748-1716.2011.02392.x

Cytokines and growth factors modify the upregulation of contractile endothelin ET(A) and ET(B) receptors in rat cerebral arteries after organ culture

H Ahnstedt, E Stenman, L Cao, M Henriksson, L Edvinsson

Klinisk Eksperimentel Forskningsafdeling Rigshospitalet

23 Citationer (Scopus)

Abstract

Experimental cerebral ischaemia and organ culture of cerebral arteries induce an increased endothelin ET(B) receptor-mediated contraction. The aim of this study was to examine whether cytokines and growth factors, known to be activated in ischaemia, can influence the expression and function of endothelin receptors after organ culture.

Originalsprog	Engelsk
Tidsskrift	Acta Physiologica
Vol/bind	205
Udgave nummer	2
Sider (fra-til)	266-78
Antal sider	13
ISSN	1748-1708
DOI	https://doi.org/10.1111/j.1748-1716.2011.02392.x
Status	Udgivet - 2012

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title = "Cytokines and growth factors modify the upregulation of contractile endothelin ET(A) and ET(B) receptors in rat cerebral arteries after organ culture",

abstract = "Experimental cerebral ischaemia and organ culture of cerebral arteries induce an increased endothelin ET(B) receptor-mediated contraction. The aim of this study was to examine whether cytokines and growth factors, known to be activated in ischaemia, can influence the expression and function of endothelin receptors after organ culture.",

keywords = "Animals, Cerebral Arteries, Dose-Response Relationship, Drug, Epidermal Growth Factor, Fibroblast Growth Factor 2, Interleukin-1beta, Male, Muscle Contraction, Organ Culture Techniques, Platelet-Derived Growth Factor, Rats, Rats, Wistar, Receptor, Endothelin A, Receptor, Endothelin B, Tumor Necrosis Factor-alpha, Up-Regulation",

author = "H Ahnstedt and E Stenman and L Cao and M Henriksson and L Edvinsson",

note = "{\textcopyright} 2011 The Authors Acta Physiologica {\textcopyright} 2011 Scandinavian Physiological Society.",

year = "2012",

doi = "10.1111/j.1748-1716.2011.02392.x",

language = "English",

volume = "205",

pages = "266--78",

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TY - JOUR

T1 - Cytokines and growth factors modify the upregulation of contractile endothelin ET(A) and ET(B) receptors in rat cerebral arteries after organ culture

AU - Ahnstedt, H

AU - Stenman, E

AU - Cao, L

AU - Henriksson, M

AU - Edvinsson, L

PY - 2012

Y1 - 2012

N2 - Experimental cerebral ischaemia and organ culture of cerebral arteries induce an increased endothelin ET(B) receptor-mediated contraction. The aim of this study was to examine whether cytokines and growth factors, known to be activated in ischaemia, can influence the expression and function of endothelin receptors after organ culture.

AB - Experimental cerebral ischaemia and organ culture of cerebral arteries induce an increased endothelin ET(B) receptor-mediated contraction. The aim of this study was to examine whether cytokines and growth factors, known to be activated in ischaemia, can influence the expression and function of endothelin receptors after organ culture.

KW - Animals

KW - Cerebral Arteries

KW - Dose-Response Relationship, Drug

KW - Epidermal Growth Factor

KW - Fibroblast Growth Factor 2

KW - Interleukin-1beta

KW - Male

KW - Muscle Contraction

KW - Organ Culture Techniques

KW - Platelet-Derived Growth Factor

KW - Rats

KW - Rats, Wistar

KW - Receptor, Endothelin A

KW - Receptor, Endothelin B

KW - Tumor Necrosis Factor-alpha

KW - Up-Regulation

UR - https://www.scopus.com/pages/publications/84860249292

U2 - 10.1111/j.1748-1716.2011.02392.x

DO - 10.1111/j.1748-1716.2011.02392.x

M3 - Journal article

C2 - 22145714

SN - 1748-1708

VL - 205

SP - 266

EP - 278

JO - Acta Physiologica

JF - Acta Physiologica

IS - 2

ER -

Cytokines and growth factors modify the upregulation of contractile endothelin ET(A) and ET(B) receptors in rat cerebral arteries after organ culture

Abstract

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