Cytochrome P4502E1 inhibition by propylene glycol prevents acetaminophen (paracetamol) hepatotoxicity in mice without cytochrome P4501A2 inhibition

Keyphrases

• Acetaminophen 100%
• Propylene Glycol 100%
• Cytochrome P450 1A2 (CYP1A2) 100%
• Cytochrome P450 2E1 (CYP2E1) 100%
• Paracetamol Hepatotoxicity 100%
• Fluvoxamine 80%
• Bioactivation 40%
• Acetaminophen Hepatotoxicity 40%
• Liver 20%
• Glutathione 20%
• Caffeine 20%
• Relative Contribution 20%
• NMRI Mice 20%
• Chlorzoxazone 20%
• Hepatotoxic 20%
• Serum Alanine Aminotransferase 20%
• Body Weight Ratio 20%
• Reactive Metabolites 20%
• Biotransformation 20%
• Aminotransferase Activity 20%
• N-acetyl-p-benzoquinone Imine 20%
• P450 20%
• Hepatoxicity 20%
• Cytochrome P-450 CYP1A2 20%
• Cytochrome P-450 CYP2E1 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Mouse 100%
• Hepatotoxicity 100%
• Paracetamol 100%
• Cytochrome 100%
• Propylene Glycol 100%
• CYP1A2 57%
• Fluvoxamine 57%
• CYP2E1 57%
• Bioactivation 28%
• Alanine Aminotransferase 14%
• Cytochrome P450 14%
• Glutathione 14%
• NMRI Mouse 14%
• Acetic Acid Derivative 14%
• Chlorzoxazone 14%
• 1,4 Benzoquinone 14%
• Imine 14%