Abstrakt
Cysteinyl-leukotrienes (cys-LT) are powerful spasmogenic and immune modulating lipid mediators involved in inflammatory diseases, in particular asthma. Here, we investigated whether cys-LT signaling, in the context of atherosclerotic heart disease, compromises the myocardial microcirculation and its response to hypoxic stress. To this end, we examined Apoe(-/-) mice fed a hypercholesterolemic diet and analysed the expression of key enzymes of the cys-LT pathway and their receptors (CysLT1/CysLT2) in normal and hypoxic myocardium as well as the potential contribution of cys-LT signaling to the acute myocardial response to hypoxia.
Originalsprog | Engelsk |
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Tidsskrift | P L o S One |
Vol/bind | 7 |
Udgave nummer | 7 |
Sider (fra-til) | e41786 |
ISSN | 1932-6203 |
DOI | |
Status | Udgivet - 2012 |