Cysteinyl leukotriene signaling aggravates myocardial hypoxia in experimental atherosclerotic heart disease

Elena Nobili, M Dolores Salvado, Lasse Westergaard Folkersen, Laura Castiglioni, Jens Kastrup, Anders Wetterholm, Elena Tremoli, Göran K Hansson, Luigi Sironi, Jesper Z Haeggström, Anders Gabrielsen

    27 Citationer (Scopus)

    Abstract

    Cysteinyl-leukotrienes (cys-LT) are powerful spasmogenic and immune modulating lipid mediators involved in inflammatory diseases, in particular asthma. Here, we investigated whether cys-LT signaling, in the context of atherosclerotic heart disease, compromises the myocardial microcirculation and its response to hypoxic stress. To this end, we examined Apoe(-/-) mice fed a hypercholesterolemic diet and analysed the expression of key enzymes of the cys-LT pathway and their receptors (CysLT1/CysLT2) in normal and hypoxic myocardium as well as the potential contribution of cys-LT signaling to the acute myocardial response to hypoxia.
    OriginalsprogEngelsk
    TidsskriftP L o S One
    Vol/bind7
    Udgave nummer7
    Sider (fra-til)e41786
    ISSN1932-6203
    DOI
    StatusUdgivet - 2012

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