Cysteinyl leukotriene signaling aggravates myocardial hypoxia in experimental atherosclerotic heart disease

Elena Nobili; M Dolores Salvado; Lasse Westergaard Folkersen; Laura Castiglioni; Jens Kastrup; Anders Wetterholm; Elena Tremoli; Göran K Hansson; Luigi Sironi; Jesper Z Haeggström; Anders Gabrielsen

doi:10.1371/journal.pone.0041786

Cysteinyl leukotriene signaling aggravates myocardial hypoxia in experimental atherosclerotic heart disease

Elena Nobili, M Dolores Salvado, Lasse Westergaard Folkersen, Laura Castiglioni, Jens Kastrup, Anders Wetterholm, Elena Tremoli, Göran K Hansson, Luigi Sironi, Jesper Z Haeggström, Anders Gabrielsen

28 Citationer (Scopus)

Abstract

Cysteinyl-leukotrienes (cys-LT) are powerful spasmogenic and immune modulating lipid mediators involved in inflammatory diseases, in particular asthma. Here, we investigated whether cys-LT signaling, in the context of atherosclerotic heart disease, compromises the myocardial microcirculation and its response to hypoxic stress. To this end, we examined Apoe(-/-) mice fed a hypercholesterolemic diet and analysed the expression of key enzymes of the cys-LT pathway and their receptors (CysLT1/CysLT2) in normal and hypoxic myocardium as well as the potential contribution of cys-LT signaling to the acute myocardial response to hypoxia.

Originalsprog	Engelsk
Tidsskrift	P L o S One
Vol/bind	7
Udgave nummer	7
Sider (fra-til)	e41786
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0041786
Status	Udgivet - 2012

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10.1371/journal.pone.0041786

Citationsformater

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title = "Cysteinyl leukotriene signaling aggravates myocardial hypoxia in experimental atherosclerotic heart disease",

abstract = "Cysteinyl-leukotrienes (cys-LT) are powerful spasmogenic and immune modulating lipid mediators involved in inflammatory diseases, in particular asthma. Here, we investigated whether cys-LT signaling, in the context of atherosclerotic heart disease, compromises the myocardial microcirculation and its response to hypoxic stress. To this end, we examined Apoe(-/-) mice fed a hypercholesterolemic diet and analysed the expression of key enzymes of the cys-LT pathway and their receptors (CysLT1/CysLT2) in normal and hypoxic myocardium as well as the potential contribution of cys-LT signaling to the acute myocardial response to hypoxia.",

author = "Elena Nobili and Salvado, {M Dolores} and Folkersen, {Lasse Westergaard} and Laura Castiglioni and Jens Kastrup and Anders Wetterholm and Elena Tremoli and Hansson, {G{\"o}ran K} and Luigi Sironi and Haeggstr{\"o}m, {Jesper Z} and Anders Gabrielsen",

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TY - JOUR

T1 - Cysteinyl leukotriene signaling aggravates myocardial hypoxia in experimental atherosclerotic heart disease

AU - Nobili, Elena

AU - Salvado, M Dolores

AU - Folkersen, Lasse Westergaard

AU - Castiglioni, Laura

AU - Kastrup, Jens

AU - Wetterholm, Anders

AU - Tremoli, Elena

AU - Hansson, Göran K

AU - Sironi, Luigi

AU - Haeggström, Jesper Z

AU - Gabrielsen, Anders

PY - 2012

Y1 - 2012

N2 - Cysteinyl-leukotrienes (cys-LT) are powerful spasmogenic and immune modulating lipid mediators involved in inflammatory diseases, in particular asthma. Here, we investigated whether cys-LT signaling, in the context of atherosclerotic heart disease, compromises the myocardial microcirculation and its response to hypoxic stress. To this end, we examined Apoe(-/-) mice fed a hypercholesterolemic diet and analysed the expression of key enzymes of the cys-LT pathway and their receptors (CysLT1/CysLT2) in normal and hypoxic myocardium as well as the potential contribution of cys-LT signaling to the acute myocardial response to hypoxia.

AB - Cysteinyl-leukotrienes (cys-LT) are powerful spasmogenic and immune modulating lipid mediators involved in inflammatory diseases, in particular asthma. Here, we investigated whether cys-LT signaling, in the context of atherosclerotic heart disease, compromises the myocardial microcirculation and its response to hypoxic stress. To this end, we examined Apoe(-/-) mice fed a hypercholesterolemic diet and analysed the expression of key enzymes of the cys-LT pathway and their receptors (CysLT1/CysLT2) in normal and hypoxic myocardium as well as the potential contribution of cys-LT signaling to the acute myocardial response to hypoxia.

U2 - 10.1371/journal.pone.0041786

DO - 10.1371/journal.pone.0041786

M3 - Journal article

C2 - 22848603

SN - 1932-6203

VL - 7

SP - e41786

JO - P L o S One

JF - P L o S One

IS - 7

ER -

Cysteinyl leukotriene signaling aggravates myocardial hypoxia in experimental atherosclerotic heart disease

Abstract

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