Cut-off levels and diagnostic accuracy of infliximab trough levels and anti-infliximab antibodies in Crohn's disease

Casper Steenholdt; Klaus Bendtzen; Jørn Brynskov; Ole Østergaard Thomsen; Mark Andrew Ainsworth

doi:10.3109/00365521.2010.536254

Cut-off levels and diagnostic accuracy of infliximab trough levels and anti-infliximab antibodies in Crohn's disease

Casper Steenholdt, Klaus Bendtzen, Jørn Brynskov, Ole Østergaard Thomsen, Mark Andrew Ainsworth

Mave-, Tarm- og Leversygdomme

180 Citationer (Scopus)

Abstract

Reasons for infliximab failure in Crohn's disease and ulcerative colitis are debated. Serum levels of infliximab and anti-infliximab antibodies have been associated with loss of response. We aimed at determining cut-off levels for infliximab and anti-infliximab antibody concentrations associated with clinical response to infliximab maintenance therapy.

Originalsprog	Engelsk
Tidsskrift	Scandinavian Journal of Gastroenterology
Vol/bind	46
Udgave nummer	3
Sider (fra-til)	310-8
Antal sider	9
ISSN	0036-5521
DOI	https://doi.org/10.3109/00365521.2010.536254
Status	Udgivet - 1 mar. 2011

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10.3109/00365521.2010.536254

Citationsformater

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title = "Cut-off levels and diagnostic accuracy of infliximab trough levels and anti-infliximab antibodies in Crohn's disease",

abstract = "Reasons for infliximab failure in Crohn's disease and ulcerative colitis are debated. Serum levels of infliximab and anti-infliximab antibodies have been associated with loss of response. We aimed at determining cut-off levels for infliximab and anti-infliximab antibody concentrations associated with clinical response to infliximab maintenance therapy.",

author = "Casper Steenholdt and Klaus Bendtzen and J{\o}rn Brynskov and Thomsen, {Ole {\O}stergaard} and Ainsworth, {Mark Andrew}",

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T1 - Cut-off levels and diagnostic accuracy of infliximab trough levels and anti-infliximab antibodies in Crohn's disease

AU - Steenholdt, Casper

AU - Bendtzen, Klaus

AU - Brynskov, Jørn

AU - Thomsen, Ole Østergaard

AU - Ainsworth, Mark Andrew

PY - 2011/3/1

Y1 - 2011/3/1

N2 - Reasons for infliximab failure in Crohn's disease and ulcerative colitis are debated. Serum levels of infliximab and anti-infliximab antibodies have been associated with loss of response. We aimed at determining cut-off levels for infliximab and anti-infliximab antibody concentrations associated with clinical response to infliximab maintenance therapy.

AB - Reasons for infliximab failure in Crohn's disease and ulcerative colitis are debated. Serum levels of infliximab and anti-infliximab antibodies have been associated with loss of response. We aimed at determining cut-off levels for infliximab and anti-infliximab antibody concentrations associated with clinical response to infliximab maintenance therapy.

U2 - 10.3109/00365521.2010.536254

DO - 10.3109/00365521.2010.536254

M3 - Journal article

C2 - 21087119

SN - 0036-5521

VL - 46

SP - 310

EP - 318

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

IS - 3

ER -

Cut-off levels and diagnostic accuracy of infliximab trough levels and anti-infliximab antibodies in Crohn's disease

Abstract

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