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Current understanding of thalamic structure and function in migraine

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@article{79f594c8acaf45cb8e431c9f39ae0237,
title = "Current understanding of thalamic structure and function in migraine",
abstract = "OBJECTIVE: To review and discuss the literature on the role of thalamic structure and function in migraine.DISCUSSION: The thalamus holds an important position in our understanding of allodynia, central sensitization and photophobia in migraine. Structural and functional findings suggest abnormal functional connectivity between the thalamus and various cortical regions pointing towards an altered pain processing in migraine. Pharmacological nociceptive modulation suggests that the thalamus is a potential drug target.CONCLUSION: A critical role for the thalamus in migraine-related allodynia and photophobia is well established. Additionally, the thalamus is most likely involved in the dysfunctional pain modulation and processing in migraine, but further research is needed to clarify the exact clinical implications of these findings.",
author = "Samaira Younis and Anders Hougaard and Rodrigo Noseda and Messoud Ashina",
year = "2019",
doi = "10.1177/0333102418791595",
language = "English",
volume = "39",
pages = "1675--1682",
journal = "Cephalalgia",
issn = "0333-1024",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "13",

}

RIS

TY - JOUR

T1 - Current understanding of thalamic structure and function in migraine

AU - Younis, Samaira

AU - Hougaard, Anders

AU - Noseda, Rodrigo

AU - Ashina, Messoud

PY - 2019

Y1 - 2019

N2 - OBJECTIVE: To review and discuss the literature on the role of thalamic structure and function in migraine.DISCUSSION: The thalamus holds an important position in our understanding of allodynia, central sensitization and photophobia in migraine. Structural and functional findings suggest abnormal functional connectivity between the thalamus and various cortical regions pointing towards an altered pain processing in migraine. Pharmacological nociceptive modulation suggests that the thalamus is a potential drug target.CONCLUSION: A critical role for the thalamus in migraine-related allodynia and photophobia is well established. Additionally, the thalamus is most likely involved in the dysfunctional pain modulation and processing in migraine, but further research is needed to clarify the exact clinical implications of these findings.

AB - OBJECTIVE: To review and discuss the literature on the role of thalamic structure and function in migraine.DISCUSSION: The thalamus holds an important position in our understanding of allodynia, central sensitization and photophobia in migraine. Structural and functional findings suggest abnormal functional connectivity between the thalamus and various cortical regions pointing towards an altered pain processing in migraine. Pharmacological nociceptive modulation suggests that the thalamus is a potential drug target.CONCLUSION: A critical role for the thalamus in migraine-related allodynia and photophobia is well established. Additionally, the thalamus is most likely involved in the dysfunctional pain modulation and processing in migraine, but further research is needed to clarify the exact clinical implications of these findings.

U2 - 10.1177/0333102418791595

DO - 10.1177/0333102418791595

M3 - Journal article

C2 - 30079744

VL - 39

SP - 1675

EP - 1682

JO - Cephalalgia

JF - Cephalalgia

SN - 0333-1024

IS - 13

ER -

ID: 58933365