TY - JOUR
T1 - Current advances in diabetic neuropathy
T2 - Proteins as therapeutic targets
AU - Kaur, Gurjeet
AU - Ali, Salaha Osman
AU - Santos, Alberto
AU - Okdahl, Tina
AU - Wegeberg, Anne Marie
AU - Ahluwalia, Tarunveer S.
AU - Hansen, Christian Stevns
AU - Wishart, David
AU - Albrechtsen, Nicolai J. Wewer
AU - Brock, Birgitte
AU - Jensen, Troels Staehelin
AU - Rossing, Peter
AU - Brock, Christina
AU - Legido-Quigley, Cristina
AU - Sulek, Karolina
N1 - Publisher Copyright:
© 2025 The Authors
PY - 2025/10/17
Y1 - 2025/10/17
N2 - Diabetic neuropathy is a debilitating complication of diabetes characterized by nerve damage that may lead to numbness, foot ulcers, and amputations, and is a major cause of morbidity and mortality in people with diabetes. There are no treatments available for diabetic neuropathy aside from pain management. Recent advances in protein research have identified potential targets associated with the disease development and progression. This review explores the latest studies identifying proteins as possible drug targets in diabetic neuropathy and their role in relevant processes such as polyol metabolism, oxidative stress, and cytokine regulation. Additionally, we provide a comprehensive view of current developments and discoveries at single cell and spatial resolution that have revealed deregulated protein profiles in the dorsal root ganglia, sciatic nerve, trigeminal ganglion, or Schwann cells. Finally, we discuss the benefits of proteomics technologies to identify proteins and associated signaling pathways to better understand the source of diabetic neuropathy.
AB - Diabetic neuropathy is a debilitating complication of diabetes characterized by nerve damage that may lead to numbness, foot ulcers, and amputations, and is a major cause of morbidity and mortality in people with diabetes. There are no treatments available for diabetic neuropathy aside from pain management. Recent advances in protein research have identified potential targets associated with the disease development and progression. This review explores the latest studies identifying proteins as possible drug targets in diabetic neuropathy and their role in relevant processes such as polyol metabolism, oxidative stress, and cytokine regulation. Additionally, we provide a comprehensive view of current developments and discoveries at single cell and spatial resolution that have revealed deregulated protein profiles in the dorsal root ganglia, sciatic nerve, trigeminal ganglion, or Schwann cells. Finally, we discuss the benefits of proteomics technologies to identify proteins and associated signaling pathways to better understand the source of diabetic neuropathy.
KW - Endocrinology
KW - Human metabolism
KW - Pathology
UR - http://www.scopus.com/inward/record.url?scp=105015349032&partnerID=8YFLogxK
U2 - 10.1016/j.isci.2025.113466
DO - 10.1016/j.isci.2025.113466
M3 - Review
C2 - 41169500
AN - SCOPUS:105015349032
SN - 2589-0042
VL - 28
JO - iScience
JF - iScience
IS - 10
M1 - 113466
ER -