Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Cryopreserved ovarian cortex from patients with leukemia in complete remission contains no apparent viable malignant cells

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Low vs. high hemoglobin trigger for Transfusion in Vascular surgery (TV): a randomized clinical feasibility trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Short regimen of rituximab plus lenalidomide in follicular lymphoma patients in need of first-line therapy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. The preleukemic TCF3-PBX1 gene fusion can be generated in utero and is present in ≈0.6% of healthy newborns

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  4. Yet another susceptibility variant for ALL: what's next?

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  5. A small change makes a big difference in Hodgkin lymphoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Gene Expression in Granulosa Cells From Small Antral Follicles From Women With or Without Polycystic Ovaries

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Quantitative Differences in TGF-β Family Members Measured in Small Antral Follicle Fluids From Women With or Without PCO

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Xeno-Free Propagation of Spermatogonial Stem Cells from Infant Boys

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer
Some women suffering from leukemia require bone marrow transplantation to be cured. Bone marrow transplantation is associated with a high risk of sterility and some patients are offered fertility preservation by cryopreservation of ovarian cortex. Transplantation of ovarian cortex to women cured of leukemia, who became menopausal, is currently not performed due to the risk of introducing the disease. In this study, individual pieces of ovarian cortex intended for reimplantation from 25 patients with leukemia were transplanted to each of 25 nude mice for 20 weeks. The ovarian cortex was examined before and after transplantation by histology and immunohistochemistry, and reverse transcription quantitative polymerase chain reaction (RT-qPCR) (in the seven patients with a known marker). Seventeen patients had ovarian cortex retrieved when they were in complete remission. Before transplantation four of seven pieces (two from patients in complete remission) of ovarian cortex had a positive RT-qPCR. After transplantation, none of the mice revealed any sign of disease neither in the pieces of ovarian cortex transplanted nor in any of the murine organs evaluated. Thus, the ovaries from patients in complete remission do not appear to contain viable malignant cells contrasting ovarian tissue retrieved prior to treatment.
OriginalsprogEngelsk
TidsskriftBlood
Vol/bind120
Udgave nummer22
Sider (fra-til)4311-4316
ISSN0006-4971
DOI
StatusUdgivet - 2012

ID: 36330514