Cryopreservation of ovarian tissue as fertility preservation in young women with multiple sclerosis before stem cell transplantation

Lotte Berdiin Colmorn; Stine Gry Kristensen; Elisabeth Clare Larsen; Kirsten Tryde Macklon

doi:10.1016/j.msard.2023.104716

Cryopreservation of ovarian tissue as fertility preservation in young women with multiple sclerosis before stem cell transplantation

Lotte Berdiin Colmorn, Stine Gry Kristensen, Elisabeth Clare Larsen, Kirsten Tryde Macklon^*

^*Corresponding author af dette arbejde

2 Citationer (Scopus)

Abstract

BACKGROUND: Women of fertile age who receive autologous hematopoietic stem cell transplantation (AHSCT) due to multiple sclerosis (MS) are at risk of loss of ovarian function and infertility because of the conditioning regimen with alkylating agents.

OBJECTIVE: To present our data on fertility preservation by ovarian tissue cryopreservation (OTC) in young women with MS before AHSCT.

METHODS: Retrospective, observational cohort study RESULTS: Eight women had OTC. After AHSCT four had premature ovarian insufficiency (POI), and two of these had autotransplantation of their cryopreserved ovarian tissue. Both women regained ovarian function, and a spontaneous pregnancy was achieved resulting in the delivery of a healthy baby.

CONCLUSION: OTC preserves fertility in young women with MS at risk of POI.

Originalsprog	Engelsk
Artikelnummer	104716
Tidsskrift	Multiple Sclerosis and Related Disorders
Vol/bind	74
ISSN	2211-0348
DOI	https://doi.org/10.1016/j.msard.2023.104716
Status	Udgivet - 2023

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10.1016/j.msard.2023.104716

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@article{9c1ff27882664ebdb65a3f4f7a6cb8d4,

title = "Cryopreservation of ovarian tissue as fertility preservation in young women with multiple sclerosis before stem cell transplantation",

abstract = "BACKGROUND: Women of fertile age who receive autologous hematopoietic stem cell transplantation (AHSCT) due to multiple sclerosis (MS) are at risk of loss of ovarian function and infertility because of the conditioning regimen with alkylating agents.OBJECTIVE: To present our data on fertility preservation by ovarian tissue cryopreservation (OTC) in young women with MS before AHSCT.METHODS: Retrospective, observational cohort study RESULTS: Eight women had OTC. After AHSCT four had premature ovarian insufficiency (POI), and two of these had autotransplantation of their cryopreserved ovarian tissue. Both women regained ovarian function, and a spontaneous pregnancy was achieved resulting in the delivery of a healthy baby.CONCLUSION: OTC preserves fertility in young women with MS at risk of POI.",

keywords = "Cryopreservation, Fertility preservation, Multiple sclerosis, Ovary, Stem cell transplantation",

author = "Colmorn, {Lotte Berdiin} and Kristensen, {Stine Gry} and Larsen, {Elisabeth Clare} and Macklon, {Kirsten Tryde}",

note = "Copyright {\textcopyright} 2023. Published by Elsevier B.V.",

year = "2023",

doi = "10.1016/j.msard.2023.104716",

language = "English",

volume = "74",

journal = "Multiple Sclerosis and Related Disorders",

issn = "2211-0348",

publisher = "Elsevier",

}

TY - JOUR

T1 - Cryopreservation of ovarian tissue as fertility preservation in young women with multiple sclerosis before stem cell transplantation

AU - Colmorn, Lotte Berdiin

AU - Kristensen, Stine Gry

AU - Larsen, Elisabeth Clare

AU - Macklon, Kirsten Tryde

PY - 2023

Y1 - 2023

N2 - BACKGROUND: Women of fertile age who receive autologous hematopoietic stem cell transplantation (AHSCT) due to multiple sclerosis (MS) are at risk of loss of ovarian function and infertility because of the conditioning regimen with alkylating agents.OBJECTIVE: To present our data on fertility preservation by ovarian tissue cryopreservation (OTC) in young women with MS before AHSCT.METHODS: Retrospective, observational cohort study RESULTS: Eight women had OTC. After AHSCT four had premature ovarian insufficiency (POI), and two of these had autotransplantation of their cryopreserved ovarian tissue. Both women regained ovarian function, and a spontaneous pregnancy was achieved resulting in the delivery of a healthy baby.CONCLUSION: OTC preserves fertility in young women with MS at risk of POI.

AB - BACKGROUND: Women of fertile age who receive autologous hematopoietic stem cell transplantation (AHSCT) due to multiple sclerosis (MS) are at risk of loss of ovarian function and infertility because of the conditioning regimen with alkylating agents.OBJECTIVE: To present our data on fertility preservation by ovarian tissue cryopreservation (OTC) in young women with MS before AHSCT.METHODS: Retrospective, observational cohort study RESULTS: Eight women had OTC. After AHSCT four had premature ovarian insufficiency (POI), and two of these had autotransplantation of their cryopreserved ovarian tissue. Both women regained ovarian function, and a spontaneous pregnancy was achieved resulting in the delivery of a healthy baby.CONCLUSION: OTC preserves fertility in young women with MS at risk of POI.

KW - Cryopreservation

KW - Fertility preservation

KW - Multiple sclerosis

KW - Ovary

KW - Stem cell transplantation

UR - http://www.scopus.com/inward/record.url?scp=85152910098&partnerID=8YFLogxK

U2 - 10.1016/j.msard.2023.104716

DO - 10.1016/j.msard.2023.104716

M3 - Comment/debate

C2 - 37087965

SN - 2211-0348

VL - 74

JO - Multiple Sclerosis and Related Disorders

JF - Multiple Sclerosis and Related Disorders

M1 - 104716

ER -

Cryopreservation of ovarian tissue as fertility preservation in young women with multiple sclerosis before stem cell transplantation

Abstract

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