Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Cross-sectional analysis of sleep hours and quality with sex hormones in men

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Genotype-phenotype associations in PPGLs in 59 patients with variants in SDHX genes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Levels of endocrine-disrupting chemicals are associated with changes in the peri-pubertal epigenome

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Sacubitril/valsartan increases postprandial gastrin and cholecystokinin in plasma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Role of fasting duration and weekday in incretin and glucose regulation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. No detectable effect of a type 2 diabetes-associated TCF7L2 genotype on the incretin effect

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Genome-Wide Association Analysis of Pancreatic Beta Cell Glucose Sensitivity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. FUT2-ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Reduced total hours of sleep and low quality of sleep have been suggested to be associated with low levels of male hormones. Few studies have examined the association between excessive sleep and male reproductive hormones.

OBJECTIVE: To investigate the association of total hours of sleep and quality of sleep with serum levels of total-, bioavailable- and free testosterone (tT, bT and fT), sex hormone binding globulin (SHBG) and dehydroepiandrosteron-sulfat (DHEAS).

METHODS: Serum levels of tT, SHBG and DHEAS were measured with immunoassays in a cross-sectional population-based study of 2,095 males. bT and fT were calculated in accordance with Vermeulens method. Information on total hours of sleep and sleep quality was obtained by questionnaire. Linear regression as used to calculate hormones according to total hours of sleep and the results were expressed as β-estimates and 95% confidence intervals (CI). The adjustment in the multivariable models was constructed taking age, bmi, smoking, alcohol intake and physical activity into account.

RESULTS: Excessive sleep (> 9 hours) compared to 7-9 hours of sleep was significantly associated with lower tT, bT and fT, but not with SHBG or DHEAS. These significant associations were also found in our analyses with hormones as continuous variables but no associations were found in our general additive model analyses.

CONCLUSIONS: In this cross-sectional study in men, excessive sleep, associated with lower levels of male reproductive hormones. Longitudinal studies are needed to determine the causal direction of the observed association between excessive sleep and lower male reproductive hormones levels.

OriginalsprogEngelsk
TidsskriftEndocrine Connections
Vol/bind8
Udgave nummer2
Sider (fra-til)141-149
Antal sider9
ISSN2049-3614
DOI
StatusUdgivet - 2019

ID: 56349471