Cross-species ChIP-seq studies provide insights into regulatory strategies of PPARγ in adipocytes

Søren F Schmidt, Mette Jørgensen, Albin Sandelin, Susanne Mandrup

Abstract

Three recent studies have investigated interspecies retention of binding sites of peroxisome proliferator-activated receptor γ (PPARγ), the master regulator of adipocyte differention, between mouse and human adipocytes. Here we discuss the major findings and demonstrate that retention of binding events is highly context-dependent.

OriginalsprogEngelsk
TidsskriftTranscription
Vol/bind3
Udgave nummer1
Sider (fra-til)19-24
Antal sider6
ISSN2154-1272
DOI
StatusUdgivet - 30 mar. 2012
Udgivet eksterntJa

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