TY - JOUR
T1 - Cross-sectional study of aortic valve calcification and cardiovascular risk factors in older Danish men
AU - Khurrami, Lida
AU - Møller, Jacob Eifer
AU - Lindholt, Jes Sanddal
AU - Urbonaviciene, Grazina
AU - Steffensen, Flemming Hald
AU - Lambrechtsen, Jess
AU - Karon, Marek
AU - Frost, Lars
AU - Busk, Martin
AU - Egstrup, Kenneth
AU - Fredgart, Maise Høigaard
AU - Diederichsen, Axel Cosmus Pyndt
N1 - © Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2021/10
Y1 - 2021/10
N2 - OBJECTIVE: Aortic valve calcification (AVC) and coronary artery calcification (CAC) are predictors of cardiovascular disease (CVD), presumably sharing risk factors. Our objectives were to determine the prevalence and extent of AVC in a large population of men aged 60-74 years and to assess the association between AVC and cardiovascular risk factors including CAC and biomarkers.METHODS: Participants from the DANish CArdioVAscular Screening and intervention trial (DANCAVAS) with AVC and CAC scores and without previous valve replacement were included in the study. Calcification scores were calculated on non-contrast CT scans. Cardiovascular risk factors were self-reported, measured or both, and further explored using descriptive and regression analysis for AVC association.RESULTS: 14 073 men aged 60-74 years were included. The AVC scores ranged from 0 to 9067 AU, with a median AVC of 6 AU (IQR 0-82). In 8156 individuals (58.0%), the AVC score was >0 and 215 (1.5%) had an AVC score ≥1200. In the regression analysis, all cardiovascular risk factors were associated with AVC; however, after inclusion of CAC ≥400, only age (ratio of expected counts (REC) 1.07 (95% CI 1.06 to 1.09)), hypertension (REC 1.24 (95% CI 1.09 to 1.41)), obesity (REC 1.34 (95% CI 1.20 to 1.50)), known CVD (REC 1.16 (95% CI 1.03 to 1.31)) and serum phosphate (REC 2.25 (95% CI 1.66 to 3.10) remained significantly associated, while smoking, diabetes, hyperlipidaemia, estimated glomerular filtration rate and serum calcium were not.CONCLUSIONS: AVC was prevalent in the general population of men aged 60-74 years and was significantly associated with all modifiable cardiovascular risk factors, but only selectively after adjustment for CAC ≥400 AU.TRIAL REGISTRATION NUMBER: NCT03946410 and ISRCTN12157806.
AB - OBJECTIVE: Aortic valve calcification (AVC) and coronary artery calcification (CAC) are predictors of cardiovascular disease (CVD), presumably sharing risk factors. Our objectives were to determine the prevalence and extent of AVC in a large population of men aged 60-74 years and to assess the association between AVC and cardiovascular risk factors including CAC and biomarkers.METHODS: Participants from the DANish CArdioVAscular Screening and intervention trial (DANCAVAS) with AVC and CAC scores and without previous valve replacement were included in the study. Calcification scores were calculated on non-contrast CT scans. Cardiovascular risk factors were self-reported, measured or both, and further explored using descriptive and regression analysis for AVC association.RESULTS: 14 073 men aged 60-74 years were included. The AVC scores ranged from 0 to 9067 AU, with a median AVC of 6 AU (IQR 0-82). In 8156 individuals (58.0%), the AVC score was >0 and 215 (1.5%) had an AVC score ≥1200. In the regression analysis, all cardiovascular risk factors were associated with AVC; however, after inclusion of CAC ≥400, only age (ratio of expected counts (REC) 1.07 (95% CI 1.06 to 1.09)), hypertension (REC 1.24 (95% CI 1.09 to 1.41)), obesity (REC 1.34 (95% CI 1.20 to 1.50)), known CVD (REC 1.16 (95% CI 1.03 to 1.31)) and serum phosphate (REC 2.25 (95% CI 1.66 to 3.10) remained significantly associated, while smoking, diabetes, hyperlipidaemia, estimated glomerular filtration rate and serum calcium were not.CONCLUSIONS: AVC was prevalent in the general population of men aged 60-74 years and was significantly associated with all modifiable cardiovascular risk factors, but only selectively after adjustment for CAC ≥400 AU.TRIAL REGISTRATION NUMBER: NCT03946410 and ISRCTN12157806.
KW - Aged
KW - Aortic Valve Stenosis/diagnosis
KW - Aortic Valve/diagnostic imaging
KW - Calcinosis/diagnosis
KW - Cardiovascular Diseases/epidemiology
KW - Cross-Sectional Studies
KW - Denmark/epidemiology
KW - Heart Disease Risk Factors
KW - Humans
KW - Male
KW - Middle Aged
KW - Prevalence
KW - Risk Assessment/methods
KW - Severity of Illness Index
KW - Tomography, X-Ray Computed
UR - http://www.scopus.com/inward/record.url?scp=85112742303&partnerID=8YFLogxK
U2 - 10.1136/heartjnl-2021-319023
DO - 10.1136/heartjnl-2021-319023
M3 - Journal article
C2 - 34376488
SN - 1355-6037
VL - 107
SP - 1536
EP - 1543
JO - Heart (British Cardiac Society)
JF - Heart (British Cardiac Society)
IS - 19
M1 - 319023
ER -