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Could Experimental Inflammation Provide Better Understanding of Migraines?

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

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  2. Identifying molecular targets in trigeminal nociception

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  3. Repair-related molecular changes during recovery phase of ischemic stroke in female rats

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  4. Changes in P2Y6 receptor-mediated vasoreactivity following focal and global ischemia

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Vis graf over relationer

Migraines constitute a common neurological and headache disorder affecting around 15% of the world's population. In addition to other mechanisms, neurogenic neuroinflammation has been proposed to play a part in migraine chronification, which includes peripheral and central sensitization. There is therefore considerable evidence suggesting that inflammation in the intracranial meninges could be a key element in addition to calcitonin gene-related peptide (CGRP), leading to sensitization of trigeminal meningeal nociceptors in migraines. There are several studies that have utilized this approach, with a strong focus on using inflammatory animal models. Data from these studies show that the inflammatory process involves sensitization of trigeminovascular afferent nerve terminals. Further, by applying a wide range of different pharmacological interventions, insight has been gained on the pathways involved. Importantly, we discuss how animal models should be used with care and that it is important to evaluate outcomes in the light of migraine pathology.

OriginalsprogEngelsk
Artikelnummer2444
TidsskriftCells
Vol/bind11
Udgave nummer15
Antal sider17
ISSN2073-4409
DOI
StatusUdgivet - 6 aug. 2022

ID: 80366135