Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

Cortical thickness following electroconvulsive therapy in patients with depression - a longitudinal MRI study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Det Danske ECT/MRI projekt

    Projekt: Typer af projekter

  1. The association between depressive mood and ischemic heart disease: a twin study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Lithium as the drug of choice for maintenance treatment in bipolar disorder

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Genome-wide gene expression in a pharmacological hormonal transition model and its relation to depressive symptoms

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Alcohol and delirium tremens: effects of average number of drinks per day and beverage type

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Parental alcohol use disorder with and without other mental disorders and offspring alcohol use disorder

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Er du bare trist, eller har du en depression? Få professorens råd

    Publikation: Bidrag til tidsskriftBidrag til avis - Kommentar/debatFormidling

  2. De depressive danskere

    Publikation: Bidrag til tidsskriftBidrag til avis - Kommentar/debatFormidling

  3. NEJ IKKE DER ER GÅET INFLATION I ADHD-DIAGNOSEN!

    Publikation: Bidrag til tidsskriftBidrag til avis - Kommentar/debatFormidling

  4. The effect of antidepressants on brain volume

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Electroconvulsive therapy increases cortical thickness in depression

    Publikation: KonferencebidragPosterForskning

Vis graf over relationer

OBJECTIVE: Several studies have found an increase in hippocampal volume following electroconvulsive therapy (ECT), but the effect on cortical thickness has been less investigated. We aimed to examine the effects of ECT on cortical thickness and their associations with clinical outcome.

METHODS: Using 3 Tesla MRI-scanner, we obtained T1-weighted brain images of 18 severely depressed patients at three time points: before, right after, and six months after a series of ECT. The thickness of 68 cortical regions was extracted using Free Surfer, and Linear Mixed Model was used to analyse the longitudinal changes.

RESULTS: We found significant increases in cortical thickness of 26 regions right after a series of ECT, mainly within the frontal, temporal, and insular cortex. The thickness returned to the baseline-values at six-month follow-up. We detected no significant decreases in cortical thickness. The increase in the thickness of the right lateral orbitofrontal cortex was associated with a greater antidepressant effect, r=0.75, p=0.0005. None of the regions showed any associations with cognitive side effects.

CONCLUSIONS: The increases in cortical thickness induced by ECT are transient. Further multimodal MRI studies should examine the neural correlates of these increases and their relationship with the antidepressant effect. This article is protected by copyright. All rights reserved.

OriginalsprogEngelsk
TidsskriftActa Psychiatrica Scandinavica
ISSN0001-690X
DOI
StatusE-pub ahead of print - 2 jul. 2019

Bibliografisk note

This article is protected by copyright. All rights reserved.

ID: 57684526