Correspondence between gene expression and neurotransmitter receptor and transporter density in the human brain

Justine Y Hansen, Ross D Markello, Lauri Tuominen, Martin Nørgaard, Elena Kuzmin, Nicola Palomero-Gallagher, Alain Dagher, Bratislav Misic

Abstract

Neurotransmitter receptors modulate signaling between neurons. Thus, neurotransmitter receptors and transporters play a key role in shaping brain function. Due to the lack of comprehensive neurotransmitter receptor/transporter density datasets, microarray gene expression measuring mRNA transcripts is often used as a proxy for receptor densities. In the present report, we comprehensively test the spatial correlation between gene expression and protein density for a total of 27 neurotransmitter receptors, receptor binding-sites, and transporters across 9 different neurotransmitter systems, using both PET and autoradiography radioligand-based imaging modalities. We find poor spatial correspondences between gene expression and density for all neurotransmitter receptors and transporters except four single-protein metabotropic receptors (5-HT1A, CB1, D2, and MOR). These expression-density associations are related to gene differential stability and can vary between cortical and subcortical structures. Altogether, we recommend using direct measures of receptor and transporter density when relating neurotransmitter systems to brain structure and function.

OriginalsprogEngelsk
Artikelnummer119671
TidsskriftNeuroImage
Vol/bind264
Sider (fra-til)1-11
Antal sider11
ISSN1053-8119
DOI
StatusUdgivet - 1 dec. 2022

Fingeraftryk

Dyk ned i forskningsemnerne om 'Correspondence between gene expression and neurotransmitter receptor and transporter density in the human brain'. Sammen danner de et unikt fingeraftryk.

Citationsformater