Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections

Helena Bergsten; Martin Bruun Madsen; Francois Bergey; Ole Hyldegaard; Steinar Skrede; Per Arnell; Oddvar Oppegaard; Andreas Itzek; Anders Perner; Mattias Svensson; Anna Norrby-Teglund; INFECT Study Group

doi:10.1093/cid/ciaa022

Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections

Helena Bergsten
, Martin Bruun Madsen
, Francois Bergey
, Ole Hyldegaard
, Steinar Skrede
, Per Arnell
, Oddvar Oppegaard
, Andreas Itzek
, Anders Perner
, Mattias Svensson
, Anna Norrby-Teglund
, INFECT Study Group

30 Citationer (Scopus)

Abstract

Analyses of plasma collected pre- and post-administration of intravenous immunoglobulin G (IVIG) from patients with Group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r=-0.67, p<0.0001). One 25g-dose IVIG was sufficient to yield patient plasma neutralizing activity against streptococcal superantigens.

Originalsprog	Engelsk
Tidsskrift	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Vol/bind	71
Udgave nummer	7
Sider (fra-til)	1772-1775
Antal sider	4
ISSN	1058-4838
DOI	https://doi.org/10.1093/cid/ciaa022
Status	Udgivet - 1 okt. 2020

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10.1093/cid/ciaa022

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Bergsten, H., Madsen, M. B., Bergey, F., Hyldegaard, O., Skrede, S., Arnell, P., Oppegaard, O., Itzek, A., Perner, A., Svensson, M., Norrby-Teglund, A., & INFECT Study Group (2020). Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 71(7), 1772-1775. https://doi.org/10.1093/cid/ciaa022

Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections. / Bergsten, Helena; Madsen, Martin Bruun; Bergey, Francois et al.
I: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Bind 71, Nr. 7, 01.10.2020, s. 1772-1775.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Bergsten, H, Madsen, MB, Bergey, F, Hyldegaard, O, Skrede, S, Arnell, P, Oppegaard, O, Itzek, A, Perner, A, Svensson, M, Norrby-Teglund, A & INFECT Study Group 2020, 'Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections', Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, bind 71, nr. 7, s. 1772-1775. https://doi.org/10.1093/cid/ciaa022

Bergsten H, Madsen MB, Bergey F, Hyldegaard O, Skrede S, Arnell P et al. Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2020 okt. 1;71(7):1772-1775. doi: 10.1093/cid/ciaa022

Bergsten, Helena ; Madsen, Martin Bruun ; Bergey, Francois et al. / Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections. I: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2020 ; Bind 71, Nr. 7. s. 1772-1775.

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abstract = "Analyses of plasma collected pre- and post-administration of intravenous immunoglobulin G (IVIG) from patients with Group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r=-0.67, p<0.0001). One 25g-dose IVIG was sufficient to yield patient plasma neutralizing activity against streptococcal superantigens.",

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AU - Bergsten, Helena

AU - Madsen, Martin Bruun

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AU - Hyldegaard, Ole

AU - Skrede, Steinar

AU - Arnell, Per

AU - Oppegaard, Oddvar

AU - Itzek, Andreas

AU - Perner, Anders

AU - Svensson, Mattias

AU - Norrby-Teglund, Anna

AU - INFECT Study Group

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AB - Analyses of plasma collected pre- and post-administration of intravenous immunoglobulin G (IVIG) from patients with Group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r=-0.67, p<0.0001). One 25g-dose IVIG was sufficient to yield patient plasma neutralizing activity against streptococcal superantigens.

KW - Streptococcus pyogenes

KW - intravenous immunoglobulin G

KW - necrotizing fasciitis

KW - necrotizing soft tissue infections

KW - superantigens

KW - S treptococcus pyogenes

KW - Necrotizing soft tissue infections

KW - Necrotizing fasciitis

KW - Superantigens

KW - Intravenous immunoglobulin G

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JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

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ER -

Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections

Abstract

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