Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections

Helena Bergsten, Martin Bruun Madsen, Francois Bergey, Ole Hyldegaard, Steinar Skrede, Per Arnell, Oddvar Oppegaard, Andreas Itzek, Anders Perner, Mattias Svensson, Anna Norrby-Teglund, INFECT study group

21 Citationer (Scopus)

Abstract

Analyses of plasma collected pre- and post-administration of intravenous immunoglobulin G (IVIG) from patients with Group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r=-0.67, p<0.0001). One 25g-dose IVIG was sufficient to yield patient plasma neutralizing activity against streptococcal superantigens.

OriginalsprogEngelsk
TidsskriftClinical infectious diseases : an official publication of the Infectious Diseases Society of America
Vol/bind71
Udgave nummer7
Sider (fra-til)1772-1775
Antal sider4
ISSN1058-4838
DOI
StatusUdgivet - 1 okt. 2020

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