@article{adcb065e8ca9445c82264fe1e51c1b9f,
title = "Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections",
abstract = "Analyses of plasma collected pre- and post-administration of intravenous immunoglobulin G (IVIG) from patients with Group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r=-0.67, p<0.0001). One 25g-dose IVIG was sufficient to yield patient plasma neutralizing activity against streptococcal superantigens.",
keywords = "Streptococcus pyogenes, intravenous immunoglobulin G, necrotizing fasciitis, necrotizing soft tissue infections, superantigens, S treptococcus pyogenes, Necrotizing soft tissue infections, Necrotizing fasciitis, Superantigens, Intravenous immunoglobulin G",
author = "Helena Bergsten and Madsen, {Martin Bruun} and Francois Bergey and Ole Hyldegaard and Steinar Skrede and Per Arnell and Oddvar Oppegaard and Andreas Itzek and Anders Perner and Mattias Svensson and Anna Norrby-Teglund and {INFECT study group}",
note = "{\textcopyright} The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.",
year = "2020",
month = oct,
day = "1",
doi = "10.1093/cid/ciaa022",
language = "English",
volume = "71",
pages = "1772--1775",
journal = "Clinical infectious diseases : an official publication of the Infectious Diseases Society of America",
issn = "1058-4838",
publisher = "University of Chicago Press",
number = "7",
}