Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Correlation between HPV status at T and N sites of oropharyngeal squamous cell carcinomas

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Current state of evidence for endolymphatic sac surgery in Menière's disease: a systematic review

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Dynamic soft tissue changes in the orbit after a blowout fracture

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Indications, risk of lower airway infection, and complications to pediatric tracheotomy: report from a tertiary referral center

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Shared heritability and functional enrichment across six solid cancers

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Dynamic soft tissue changes in the orbit after a blowout fracture

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Incidence and survival of hypopharyngeal cancer: a Danish Nation-Wide Study from 1980 to 2014

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Near-infrared fluorescence imaging improves the nodal yield in neck dissection in oral cavity cancer - A randomized study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Perspektiver på recidiverende respiratorisk papillomatose og humant papillomvirus-vaccination

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

OBJECTIVES: Human papilloma virus (HPV) is known to be associated with oropharyngeal squamous cell carcinomas (OPSCC) and may potentially play a vital role in tumor metastasis. The purpose of this study was to correlate HPV status of cervical lymph node metastases with their respective primary OPSCC tumor.

METHODS: Formalin-fixed, paraffin-embedded (FFPE) tissue samples obtained from 34 patients with cervical lymph node metastases were analyzed with HPV 16 DNA polymerase chain reaction (PCR), p16 immunohistochemistry and HPV typing. The results were correlated with the HPV status and type found in the primary tumors of OPSCC.

RESULTS: Comparing HPV DNA status with p16 we found that 21 primary tumors and lymph node metastases were HPV positive (61.8%) and seven primary tumors and lymph node metastases were HPV negative (20.6%). Six patient samples differed when correlating the primary tumor and lymph node metastasis (17.6%).

CONCLUSIONS: In this study, HPV status in OPSCCs and their cervical lymph node metastases correlated in the vast majority of cases. However, HPV detection methods may have certain limitations resulting in varying degree of non-correlation. This should be taken into account when stratifying treatment in regard to HPV status.

OriginalsprogEngelsk
TidsskriftActa Oto-Laryngologica
Vol/bind137
Udgave nummer12
Sider (fra-til)1260-1264
Antal sider5
ISSN0001-6489
DOI
StatusUdgivet - dec. 2017

ID: 51769990