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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Coronary Microvascular Dysfunction: A Practical Approach to Diagnosis and Management

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

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PURPOSE OF REVIEW: The purpose of this review is to provide an overview of diagnostic and treatment considerations in patients with coronary microvascular dysfunction (CMD) in the absence of obstructive coronary artery disease (CAD).

RECENT FINDINGS: The prevalence of obstructive CAD in unselected patient populations referred for evaluation of angina is less than 10%. A significant proportion of patients with angina and no obstructive CAD have CMD, a condition associated with impaired cardiovascular prognosis. Non-invasive and invasive evaluation of coronary microvascular function is feasible and widely available, yet CMD is underdiagnosed and undertreated. A patient-tailored treatment approach guided by coronary microvascular testing shows promising results for patient-reported outcomes of symptom burden and quality of life. Coronary microvascular testing should be considered in angina patients with no obstructive CAD, before other causes of chest pain are explored. A patient-tailored treatment approach guided by a complete evaluation of epicardial anatomy and macro-and microvascular function may help optimize treatment strategy and prevent unnecessary medical interventions. More research is needed to establish the long-term effect of patient-tailored therapies on risk reduction in CMD.

OriginalsprogEngelsk
Artikelnummer54
TidsskriftCurrent Atherosclerosis Reports
Vol/bind23
Udgave nummer9
Sider (fra-til)54
ISSN1523-3804
DOI
StatusUdgivet - sep. 2021

ID: 67015289