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Cornelia de Lange Syndrome

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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Vis graf over relationer

Cornelia de Lange Syndrome (CdLS; MIM #122470, 300590, 610759, 614701, 300882) is a rare and clinically variable disorder that affects multiple organs. It is characterized by intellectual disability (mild to severe), distinctive facial features, pre- and postnatal growth retardation, and hirsutism. Congenital anomalies include malformations of the upper limbs, gastrointestinal malformation/rotation, pyloric stenosis, diaphragmatic hernia, heart defects and genitourinary malformations. Gastroesophageal reflux disease is present in almost all patients. In addition to classic forms, milder phenotypes have been reported. To date five genes (NIPBL, SMC1A, SMC3, RAD21 and HDAC8) have been associated with CdLS and mutations of these genes comprise the underlying defect in 70% of the patients. Here, we will provide a brief review of the clinical features of Cornelia de Lange syndrome, summarize the known underlying genetic defects, pre- and postnatal diagnosis possibilities, and genetic counseling.

OriginalsprogEngelsk
TidsskriftClinical Genetics
Vol/bind572
Udgave nummer1
Sider (fra-til)2015 Nov 1;572(1):130-4.
ISSN0009-9163
DOI
StatusUdgivet - 2015

ID: 44553150