Copy number variations in affective disorders and meta-analysis

Line Olsen; Thomas Hansen; Srdjan Djurovic; Eva Haastrup; Anders Albrecthsen; Louise.K.Enggaard Høffding; Anna Secher; Omar Gustafsson; Klaus D Jakobsen; Finn C Nielsen; Henrik Ullum; Gunnar Morken; Ingrid Agartz; Ingrid Melle; Ulrik Gether; Ole A Andreassen; Thomas Mears Werge

doi:10.1097/YPG.0b013e3283463deb

Copy number variations in affective disorders and meta-analysis

Line Olsen, Thomas Hansen, Srdjan Djurovic, Eva Haastrup, Anders Albrecthsen, Louise.K.Enggaard Høffding, Anna Secher, Omar Gustafsson, Klaus D Jakobsen, Finn C Nielsen, Henrik Ullum, Gunnar Morken, Ingrid Agartz, Ingrid Melle, Ulrik Gether, Ole A Andreassen, Thomas Mears Werge

2 Citationer (Scopus)

Abstract

In two recent studies 10 copy number variants (CNV) were found to be overrepresented either among patients suffering from affective disorders in an Amish family or in the Wellcome Trust Case-Control Consortium study. Here, we investigate if these variants are associated with affective disorders in a combined analysis of three case-control samples from Denmark, Norway and Iceland. A total of 1897 cases (n=1223 unipolar and n=463 bipolar) and 11 231 controls were analyzed for CNVs at the 10 genomic loci, but we found no combined association between these CNVs and affective disorders.

Originalsprog	Engelsk
Tidsskrift	Psychiatric Genetics
Vol/bind	21
Udgave nummer	6
Sider (fra-til)	319-22
Antal sider	4
ISSN	0955-8829
DOI	https://doi.org/10.1097/YPG.0b013e3283463deb
Status	Udgivet - dec. 2011

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10.1097/YPG.0b013e3283463deb

Citationsformater

Olsen, L., Hansen, T., Djurovic, S., Haastrup, E., Albrecthsen, A., Høffding, L. K. E., Secher, A., Gustafsson, O., Jakobsen, K. D., Nielsen, F. C., Ullum, H., Morken, G., Agartz, I., Melle, I., Gether, U., Andreassen, O. A., & Werge, T. M. (2011). Copy number variations in affective disorders and meta-analysis. Psychiatric Genetics, 21(6), 319-22. https://doi.org/10.1097/YPG.0b013e3283463deb

Olsen, L, Hansen, T, Djurovic, S, Haastrup, E, Albrecthsen, A, Høffding, LKE, Secher, A, Gustafsson, O, Jakobsen, KD, Nielsen, FC, Ullum, H, Morken, G, Agartz, I, Melle, I, Gether, U, Andreassen, OA & Werge, TM 2011, 'Copy number variations in affective disorders and meta-analysis', Psychiatric Genetics, bind 21, nr. 6, s. 319-22. https://doi.org/10.1097/YPG.0b013e3283463deb

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title = "Copy number variations in affective disorders and meta-analysis",

abstract = "In two recent studies 10 copy number variants (CNV) were found to be overrepresented either among patients suffering from affective disorders in an Amish family or in the Wellcome Trust Case-Control Consortium study. Here, we investigate if these variants are associated with affective disorders in a combined analysis of three case-control samples from Denmark, Norway and Iceland. A total of 1897 cases (n=1223 unipolar and n=463 bipolar) and 11 231 controls were analyzed for CNVs at the 10 genomic loci, but we found no combined association between these CNVs and affective disorders.",

author = "Line Olsen and Thomas Hansen and Srdjan Djurovic and Eva Haastrup and Anders Albrecthsen and Louise.K.Enggaard H{\o}ffding and Anna Secher and Omar Gustafsson and Jakobsen, {Klaus D} and Nielsen, {Finn C} and Henrik Ullum and Gunnar Morken and Ingrid Agartz and Ingrid Melle and Ulrik Gether and Andreassen, {Ole A} and Werge, {Thomas Mears}",

year = "2011",

month = dec,

doi = "10.1097/YPG.0b013e3283463deb",

language = "English",

volume = "21",

pages = "319--22",

journal = "Psychiatric Genetics",

issn = "0955-8829",

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TY - JOUR

T1 - Copy number variations in affective disorders and meta-analysis

AU - Olsen, Line

AU - Hansen, Thomas

AU - Djurovic, Srdjan

AU - Haastrup, Eva

AU - Albrecthsen, Anders

AU - Høffding, Louise.K.Enggaard

AU - Secher, Anna

AU - Gustafsson, Omar

AU - Jakobsen, Klaus D

AU - Nielsen, Finn C

AU - Ullum, Henrik

AU - Morken, Gunnar

AU - Agartz, Ingrid

AU - Melle, Ingrid

AU - Gether, Ulrik

AU - Andreassen, Ole A

AU - Werge, Thomas Mears

PY - 2011/12

Y1 - 2011/12

N2 - In two recent studies 10 copy number variants (CNV) were found to be overrepresented either among patients suffering from affective disorders in an Amish family or in the Wellcome Trust Case-Control Consortium study. Here, we investigate if these variants are associated with affective disorders in a combined analysis of three case-control samples from Denmark, Norway and Iceland. A total of 1897 cases (n=1223 unipolar and n=463 bipolar) and 11 231 controls were analyzed for CNVs at the 10 genomic loci, but we found no combined association between these CNVs and affective disorders.

AB - In two recent studies 10 copy number variants (CNV) were found to be overrepresented either among patients suffering from affective disorders in an Amish family or in the Wellcome Trust Case-Control Consortium study. Here, we investigate if these variants are associated with affective disorders in a combined analysis of three case-control samples from Denmark, Norway and Iceland. A total of 1897 cases (n=1223 unipolar and n=463 bipolar) and 11 231 controls were analyzed for CNVs at the 10 genomic loci, but we found no combined association between these CNVs and affective disorders.

U2 - 10.1097/YPG.0b013e3283463deb

DO - 10.1097/YPG.0b013e3283463deb

M3 - Journal article

C2 - 21451435

SN - 0955-8829

VL - 21

SP - 319

EP - 322

JO - Psychiatric Genetics

JF - Psychiatric Genetics

IS - 6

ER -

Copy number variations in affective disorders and meta-analysis

Abstract

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