TY - JOUR
T1 - Copy number variation in glutathione S-transferases M1 and T1 and ischemic vascular disease: four studies and meta-analyses
AU - Nørskov, Marianne S
AU - Frikke-Schmidt, Ruth
AU - Loft, Steffen
AU - Sillesen, Henrik
AU - Grande, Peer
AU - Nordestgaard, Børge G
AU - Tybjærg-Hansen, Anne
PY - 2011
Y1 - 2011
N2 - Glutathione S-transferases (GSTs) M1 and T1 detoxify products of oxidative stress and may protect against atherosclerosis and ischemic vascular disease (IVD). We tested the hypothesis that copy number variation (CNV) in GSTM1 and GSTT1 genes, known to be associated with stepwise decreases in catalytic activity, predict risk of IVD.
AB - Glutathione S-transferases (GSTs) M1 and T1 detoxify products of oxidative stress and may protect against atherosclerosis and ischemic vascular disease (IVD). We tested the hypothesis that copy number variation (CNV) in GSTM1 and GSTT1 genes, known to be associated with stepwise decreases in catalytic activity, predict risk of IVD.
U2 - 10.1161/CIRCGENETICS.111.959809
DO - 10.1161/CIRCGENETICS.111.959809
M3 - Journal article
C2 - 21562205
SN - 1942-325X
VL - 4
SP - 418
EP - 428
JO - Circulation: Cardiovascular Genetics
JF - Circulation: Cardiovascular Genetics
IS - 4
ER -