Copper-mediated radiochemistry: historical impact, current trends, and future possibilities

Gregory D Bowden; Marius Müller; Matthias M Herth; Melanie S Sanford; Peter J H Scott

doi:10.1038/s44303-025-00087-x

Copper-mediated radiochemistry: historical impact, current trends, and future possibilities

Gregory D Bowden, Marius Müller, Matthias M Herth, Melanie S Sanford^*, Peter J H Scott^*

^*Corresponding author af dette arbejde

Afdeling for Klinisk Fysiologi og Nuklearmedicin

Abstract

Modern approaches to copper-mediated radiolabeling have proven an important addition to the radiochemical toolbox. Radiopharmaceuticals prepared using this methodology have been translated from preclinical PET studies into clinical trials, and it has been adapted for radionuclides beyond fluorine-18, enabling theranostic applications. The methodology is also beginning to benefit from AI-assisted radiochemistry development. This perspective discusses the history, state-of-the-art, and potential future impact of copper-mediated radiochemistry on radiopharmaceutical development.

Originalsprog	Engelsk
Tidsskrift	Npj imaging
Vol/bind	3
Sider (fra-til)	25
ISSN	2948-197X
DOI	https://doi.org/10.1038/s44303-025-00087-x
Status	Udgivet - 2025

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10.1038/s44303-025-00087-xLicens: CC BY-NC-ND

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AU - Bowden, Gregory D

AU - Müller, Marius

AU - Herth, Matthias M

AU - Sanford, Melanie S

AU - Scott, Peter J H

PY - 2025

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AB - Modern approaches to copper-mediated radiolabeling have proven an important addition to the radiochemical toolbox. Radiopharmaceuticals prepared using this methodology have been translated from preclinical PET studies into clinical trials, and it has been adapted for radionuclides beyond fluorine-18, enabling theranostic applications. The methodology is also beginning to benefit from AI-assisted radiochemistry development. This perspective discusses the history, state-of-the-art, and potential future impact of copper-mediated radiochemistry on radiopharmaceutical development.

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DO - 10.1038/s44303-025-00087-x

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Copper-mediated radiochemistry: historical impact, current trends, and future possibilities

Abstract

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