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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Convergent (18)F-labeling and evaluation of N-benzyl-phenethylamines as 5-HT2A receptor PET ligands

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DOI

  1. Synthesis and evaluation of [¹¹C]Cimbi-806 as a potential PET ligand for 5-HT₇ receptor imaging

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Hot and cold cognitive disturbances in antidepressant-free patients with major depressive disorder: a NeuroPharm study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Structural brain abnormalities associated with cognitive impairments in bipolar disorder

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. NeuroPharm study: EEG wakefulness regulation as a biomarker in MDD

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  4. Parkinson patients have a presynaptic serotonergic deficit: A dynamic deep brain stimulation PET study

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Vis graf over relationer

Positron emission tomography (PET) investigations of the 5-HT2A receptor (5-HT2AR) system can be used as a research tool in diseases such as depression, Alzheimer's disease and schizophrenia. We have previously developed a (11)C-labeled agonist PET ligand ([(11)C]Cimbi-36), and the aim of this study was to identify a (18)F-labeled analogue of this PET-ligand. Thus, we developed a convergent radiochemical approach giving easy access to 5 different (18)F-labeled ligands structurally related to Cimbi-36 from a common (18)F-labeled intermediate. After intravenous injection, all ligands entered the pig brain. However, since within-scan intervention with ketanserin, a known orthosteric 5-HT2A receptor antagonist, did not result in significant blocking, the radioligands seem unsuitable for neuroimaging of the 5-HT2AR in vivo.

OriginalsprogEngelsk
TidsskriftBioorganic and Medicinal Chemistry
Vol/bind24
Udgave nummer21
Sider (fra-til)5353-5356
Antal sider4
ISSN0968-0896
DOI
StatusUdgivet - 1 nov. 2016

ID: 49675081