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Region Hovedstaden - en del af Københavns Universitetshospital
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Contribution of recruitable follicles to circulating anti-Müllerian hormone levels following maximal gonadotrophin stimulation in patients with limited ovarian reserve

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  4. Left-right differences in ovarian volume and antral follicle count in 1423 women of reproductive age

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  5. Selective use of corifollitropin for controlled ovarian stimulation for IVF in patients with low anti-Müllerian hormone

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  1. Ovarian reserve markers in women using various hormonal contraceptives

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  2. Ovarian cortical follicle density in infertile women with low anti-Müllerian hormone

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  4. Assisted reproductive technology treatment and risk of ovarian cancer-a nationwide population-based cohort study

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Vis graf over relationer

In women, the majority of anti-Müllerian hormone (AMH) measured in serum originate from small antral follicles measuring 2-10 mm. In gonadotrophin-stimulated cycles prior to assisted reproductive technology (ART), most of the recruitable follicles develop beyond 10 mm in size and thus lose their AMH secretion capacity causing declining serum AMH levels. The aim of this study was to define the residual serum AMH level after elimination of the AMH producing recruitable follicles following maximal gonadotrophin stimulation. We measured serum AMH and number of follicles according to size at several time points during a cycle of maximal gonadotrophin stimulation (fixed dose of 300 IE HP-hMG) in 107 women with low AMH (median AMH 5 pmol/L, interquartile range (IQR) 3.3-8.3). We found that AMH decreased gradually and reached a minimum level of -55.4% (95% CI -59.6; -50.7) of the baseline value four days after ovulation trigger. Our findings suggest that the residual AMH production origins from pre-antral and small antral follicles not visible by sonography and that they account for up to 40% of the circulating AMH.

OriginalsprogEngelsk
TidsskriftGynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
Sider (fra-til)1-4
Antal sider4
ISSN0951-3590
DOI
StatusUdgivet - 6 aug. 2019

ID: 57727646