Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Continuous-flow LVADs in the Nordic countries: complications and mortality and its predictors

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Relationship Between Invasive Hemodynamics and Liver Function in Advanced Heart Failure

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Atrial fibrillation and anticoagulation in patients with breast cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. A national needs assessment study to determine procedures for simulation-based training in cardiology in Denmark

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Contemporary practice of CRT implantation in scandinavia compared to Europe

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Favorable five-year outcomes for heart failure diagnosed in younger patients without severe comorbidity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Effect of Heart Rate Reserve on Exercise Capacity in Patients Treated with a Continuous Left Ventricular Assist Device

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Outcome after heart-lung or lung transplantation in patients with Eisenmenger syndrome

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Oscar Ö Braun
  • Johan Nilsson
  • Finn Gustafsson
  • Göran Dellgren
  • Arnt E Fiane
  • Karl Lemström
  • Laila Hubbert
  • Laila Hellgren
  • Lars H Lund
Vis graf over relationer

OBJECTIVES: The purpose of this study was to assess complications and mortality and its predictors, with continuous-flow left ventricular assist devices (CF-LVADs) in the Nordic Countries.

DESIGN: This was a retrospective, international, multicenter cohort study.

RESULTS: Between 1993 and 2013, 442 surgically implanted long-term mechanical assist devices were used among 8 centers in the Nordic countries. Of those, 238 were CF-LVADs (HVAD or HeartMate II) implanted in patients >18 years with complete data. Postoperative complications and survival were compared and Cox proportion hazard regression analysis was used to identify predictors of mortality. The overall Kaplan-Meier survival rate was 75% at 1 year, 69% at 2 years and 63% at 3 years. A planned strategy of destination therapy had poorer survival compared to a strategy of bridge to transplantation or decision (2-year survival of 41% vs. 76%, p < .001). The most common complications were non-driveline infections (excluding sepsis) (44%), driveline infection (27%), need for continuous renal replacement therapy (25%) and right heart failure (24%). In a multivariate model age and left ventricular diastolic dimension was left as independent risk factors for mortality with a hazard ratio of 1.35 (95% confidence interval (CI) [1.01-1.80], p = .046) per 10 years and 0.88 (95% CI [0.72-0.99], p = .044) per 5 mm, respectively.

CONCLUSION: Outcome with CF LVAD in the Nordic countries was comparable to other cohorts. Higher age and destination therapy require particularly stringent selection.

OriginalsprogEngelsk
TidsskriftScandinavian cardiovascular journal : SCJ
Vol/bind53
Udgave nummer1
Sider (fra-til)14-20
Antal sider7
ISSN1401-7431
DOI
StatusUdgivet - feb. 2019

ID: 57663980