Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Continuous EEG Monitoring in a Consecutive Patient Cohort with Sepsis and Delirium

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Global Characterisation of Coagulopathy in Isolated Traumatic Brain Injury (iTBI): A CENTER-TBI Analysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Common Data Elements for COVID-19 Neuroimaging: A GCS-NeuroCOVID Proposal

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Resting-State NIRS-EEG in Unresponsive Patients with Acute Brain Injury: A Proof-of-Concept Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Microbiome Compositions and Resistome Levels after Antibiotic Treatment of Critically Ill Patients: An Observational Cohort Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Intensive Care Antifungal Stewardship Programme Based on T2Candida PCR and Candida Mannan Antigen: A Prospective Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Prediction of survival in amyotrophic lateral sclerosis: a nationwide, Danish cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Background: Delirium is common during sepsis, although under-recognized. We aimed to assess the value of continuous electroencephalography (cEEG) to aid in the diagnosis of delirium in septic patients. Methods: We prospectively evaluated 102 consecutive patients in a medical intensive care unit (ICU), who had sepsis or septic shock, without evidence of acute primary central nervous system disease. We initiated cEEG recording immediately after identification. The median cEEG time per patient was 44 h (interquartile range 21–99 h). A total of 6723 h of cEEG recordings were examined. The Confusion Assessment Method for the ICU (CAM-ICU) was administered six times daily to identify delirium. We analyzed the correlation between cEEG and delirium using 1252 two-minute EEG sequences recorded simultaneously with the CAM-ICU scorings. Results: Of the 102 included patients, 66 (65%) had at least one delirium episode during their ICU stay, 30 (29%) remained delirium-free, and 6 (6%) were not assessable due to deep sedation or coma. The absence of delirium was independently associated with preserved high-frequency beta activity (> 13 Hz) (P < 10 −7 ) and cEEG reactivity (P < 0.001). Delirium was associated with preponderance of low-frequency cEEG activity and absence of high-frequency cEEG activity. Sporadic periodic cEEG discharges occurred in 15 patients, 13 of whom were delirious. No patient showed clinical or electrographic evidence of non-convulsive status epilepticus. Conclusions: Our findings indicate that cEEG can help distinguish septic patients with delirium from non-delirious patients.

OriginalsprogEngelsk
TidsskriftNeurocritical Care
Vol/bind32
Udgave nummer1
Sider (fra-til)121-130
Antal sider10
ISSN1541-6933
DOI
StatusUdgivet - 2020

ID: 58926383