Context-dependent associations between variation in risk of ischemic heart disease and variation in the 5' promoter region of the apolipoprotein E gene in Danish women

Jari H Stengård, Greg Dyson, Ruth Frikke-Schmidt, Anne Tybjærg-Hansen, Borge G Nordestgaard, Charles F Sing

8 Citationer (Scopus)

Abstrakt

Variations in the noncoding single-nucleotide polymorphisms (SNPs) at positions 560 and 832 in the 5' promoter region of the apolipoprotein E gene define genotypes that distinguish between high and low concentrations of plasma total and high-density lipoprotein cholesterol and triglycerides. We addressed whether these genotypes improve the prediction of ischemic heart disease (IHD) in subsamples of individuals defined by traditional risk factors and the genotypes defined by the epsilon(2), epsilon(3), and epsilon(4) alleles in exon 4 of the apolipoprotein E gene.
OriginalsprogEngelsk
TidsskriftCirculation. Cardiovascular genetics
Vol/bind3
Udgave nummer1
Sider (fra-til)22-30
Antal sider9
DOI
StatusUdgivet - 1 feb. 2010

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