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Consortium-based genome-wide meta-analysis for childhood dental caries traits

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Harvard

Haworth, S, Shungin, D, van der Tas, JT, Vucic, S, Medina-Gomez, C, Yakimov, V, Feenstra, B, Shaffer, JR, Lee, MK, Standl, M, Thiering, E, Wang, C, Bønnelykke, K, Waage, J, Jessen, LE, Nørrisgaard, PE, Joro, R, Seppälä, I, Raitakari, O, Dudding, T, Grgic, O, Ongkosuwito, E, Vierola, A, Eloranta, A-M, West, NX, Thomas, SJ, McNeil, DW, Levy, SM, Slayton, R, Nohr, EA, Lehtimäki, T, Lakka, T, Bisgaard, H, Pennell, C, Kühnisch, J, Marazita, ML, Melbye, M, Geller, F, Rivadeneira, F, Wolvius, EB, Franks, PW, Johansson, I & Timpson, NJ 2018, 'Consortium-based genome-wide meta-analysis for childhood dental caries traits' Human Molecular Genetics, bind 27, nr. 17, s. 3113-3127. https://doi.org/10.1093/hmg/ddy237

APA

Haworth, S., Shungin, D., van der Tas, J. T., Vucic, S., Medina-Gomez, C., Yakimov, V., ... Timpson, N. J. (2018). Consortium-based genome-wide meta-analysis for childhood dental caries traits. Human Molecular Genetics, 27(17), 3113-3127. https://doi.org/10.1093/hmg/ddy237

CBE

Haworth S, Shungin D, van der Tas JT, Vucic S, Medina-Gomez C, Yakimov V, Feenstra B, Shaffer JR, Lee MK, Standl M, Thiering E, Wang C, Bønnelykke K, Waage J, Jessen LE, Nørrisgaard PE, Joro R, Seppälä I, Raitakari O, Dudding T, Grgic O, Ongkosuwito E, Vierola A, Eloranta A-M, West NX, Thomas SJ, McNeil DW, Levy SM, Slayton R, Nohr EA, Lehtimäki T, Lakka T, Bisgaard H, Pennell C, Kühnisch J, Marazita ML, Melbye M, Geller F, Rivadeneira F, Wolvius EB, Franks PW, Johansson I, Timpson NJ. 2018. Consortium-based genome-wide meta-analysis for childhood dental caries traits. Human Molecular Genetics. 27(17):3113-3127. https://doi.org/10.1093/hmg/ddy237

MLA

Vancouver

Haworth S, Shungin D, van der Tas JT, Vucic S, Medina-Gomez C, Yakimov V o.a. Consortium-based genome-wide meta-analysis for childhood dental caries traits. Human Molecular Genetics. 2018 sep 1;27(17):3113-3127. https://doi.org/10.1093/hmg/ddy237

Author

Haworth, Simon ; Shungin, Dmitry ; van der Tas, Justin T ; Vucic, Strahinja ; Medina-Gomez, Carolina ; Yakimov, Victor ; Feenstra, Bjarke ; Shaffer, John R ; Lee, Myoung Keun ; Standl, Marie ; Thiering, Elisabeth ; Wang, Carol ; Bønnelykke, Klaus ; Waage, Johannes ; Jessen, Leon Eyrich ; Nørrisgaard, Pia Elisabeth ; Joro, Raimo ; Seppälä, Ilkka ; Raitakari, Olli ; Dudding, Tom ; Grgic, Olja ; Ongkosuwito, Edwin ; Vierola, Anu ; Eloranta, Aino-Maija ; West, Nicola X ; Thomas, Steven J ; McNeil, Daniel W ; Levy, Steven M ; Slayton, Rebecca ; Nohr, Ellen A ; Lehtimäki, Terho ; Lakka, Timo ; Bisgaard, Hans ; Pennell, Craig ; Kühnisch, Jan ; Marazita, Mary L ; Melbye, Mads ; Geller, Frank ; Rivadeneira, Fernando ; Wolvius, Eppo B ; Franks, Paul W ; Johansson, Ingegerd ; Timpson, Nicholas J. / Consortium-based genome-wide meta-analysis for childhood dental caries traits. I: Human Molecular Genetics. 2018 ; Bind 27, Nr. 17. s. 3113-3127.

Bibtex

@article{38d1598699504d7cab682f7f30022b0a,
title = "Consortium-based genome-wide meta-analysis for childhood dental caries traits",
abstract = "Prior studies suggest dental caries traits in children and adolescents are partially heritable, but there has been no large-scale consortium genome-wide association study (GWAS) to date. We therefore performed GWAS for caries in participants aged 2.5-18.0 years from nine contributing centres. Phenotype definitions were created for the presence or absence of treated or untreated caries, stratified by primary and permanent dentition. All studies tested for association between caries and genotype dosage and the results were combined using fixed-effects meta-analysis. Analysis included up to 19 003 individuals (7530 affected) for primary teeth and 13 353 individuals (5875 affected) for permanent teeth. Evidence for association with caries status was observed at rs1594318-C for primary teeth [intronic within ALLC, odds ratio (OR) 0.85, effect allele frequency (EAF) 0.60, P 4.13e-8] and rs7738851-A (intronic within NEDD9, OR 1.28, EAF 0.85, P 1.63e-8) for permanent teeth. Consortium-wide estimated heritability of caries was low [h2 of 1{\%} (95{\%} CI: 0{\%}: 7{\%}) and 6{\%} (95{\%} CI 0{\%}: 13{\%}) for primary and permanent dentitions, respectively] compared with corresponding within-study estimates [h2 of 28{\%} (95{\%} CI: 9{\%}: 48{\%}) and 17{\%} (95{\%} CI: 2{\%}: 31{\%})] or previously published estimates. This study was designed to identify common genetic variants with modest effects which are consistent across different populations. We found few single variants associated with caries status under these assumptions. Phenotypic heterogeneity between cohorts and limited statistical power will have contributed; these findings could also reflect complexity not captured by our study design, such as genetic effects which are conditional on environmental exposure.",
author = "Simon Haworth and Dmitry Shungin and {van der Tas}, {Justin T} and Strahinja Vucic and Carolina Medina-Gomez and Victor Yakimov and Bjarke Feenstra and Shaffer, {John R} and Lee, {Myoung Keun} and Marie Standl and Elisabeth Thiering and Carol Wang and Klaus B{\o}nnelykke and Johannes Waage and Jessen, {Leon Eyrich} and N{\o}rrisgaard, {Pia Elisabeth} and Raimo Joro and Ilkka Sepp{\"a}l{\"a} and Olli Raitakari and Tom Dudding and Olja Grgic and Edwin Ongkosuwito and Anu Vierola and Aino-Maija Eloranta and West, {Nicola X} and Thomas, {Steven J} and McNeil, {Daniel W} and Levy, {Steven M} and Rebecca Slayton and Nohr, {Ellen A} and Terho Lehtim{\"a}ki and Timo Lakka and Hans Bisgaard and Craig Pennell and Jan K{\"u}hnisch and Marazita, {Mary L} and Mads Melbye and Frank Geller and Fernando Rivadeneira and Wolvius, {Eppo B} and Franks, {Paul W} and Ingegerd Johansson and Timpson, {Nicholas J}",
year = "2018",
month = "9",
day = "1",
doi = "10.1093/hmg/ddy237",
language = "English",
volume = "27",
pages = "3113--3127",
journal = "Human Molecular Genetics",
issn = "0964-6906",
publisher = "Oxford University Press",
number = "17",

}

RIS

TY - JOUR

T1 - Consortium-based genome-wide meta-analysis for childhood dental caries traits

AU - Haworth, Simon

AU - Shungin, Dmitry

AU - van der Tas, Justin T

AU - Vucic, Strahinja

AU - Medina-Gomez, Carolina

AU - Yakimov, Victor

AU - Feenstra, Bjarke

AU - Shaffer, John R

AU - Lee, Myoung Keun

AU - Standl, Marie

AU - Thiering, Elisabeth

AU - Wang, Carol

AU - Bønnelykke, Klaus

AU - Waage, Johannes

AU - Jessen, Leon Eyrich

AU - Nørrisgaard, Pia Elisabeth

AU - Joro, Raimo

AU - Seppälä, Ilkka

AU - Raitakari, Olli

AU - Dudding, Tom

AU - Grgic, Olja

AU - Ongkosuwito, Edwin

AU - Vierola, Anu

AU - Eloranta, Aino-Maija

AU - West, Nicola X

AU - Thomas, Steven J

AU - McNeil, Daniel W

AU - Levy, Steven M

AU - Slayton, Rebecca

AU - Nohr, Ellen A

AU - Lehtimäki, Terho

AU - Lakka, Timo

AU - Bisgaard, Hans

AU - Pennell, Craig

AU - Kühnisch, Jan

AU - Marazita, Mary L

AU - Melbye, Mads

AU - Geller, Frank

AU - Rivadeneira, Fernando

AU - Wolvius, Eppo B

AU - Franks, Paul W

AU - Johansson, Ingegerd

AU - Timpson, Nicholas J

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Prior studies suggest dental caries traits in children and adolescents are partially heritable, but there has been no large-scale consortium genome-wide association study (GWAS) to date. We therefore performed GWAS for caries in participants aged 2.5-18.0 years from nine contributing centres. Phenotype definitions were created for the presence or absence of treated or untreated caries, stratified by primary and permanent dentition. All studies tested for association between caries and genotype dosage and the results were combined using fixed-effects meta-analysis. Analysis included up to 19 003 individuals (7530 affected) for primary teeth and 13 353 individuals (5875 affected) for permanent teeth. Evidence for association with caries status was observed at rs1594318-C for primary teeth [intronic within ALLC, odds ratio (OR) 0.85, effect allele frequency (EAF) 0.60, P 4.13e-8] and rs7738851-A (intronic within NEDD9, OR 1.28, EAF 0.85, P 1.63e-8) for permanent teeth. Consortium-wide estimated heritability of caries was low [h2 of 1% (95% CI: 0%: 7%) and 6% (95% CI 0%: 13%) for primary and permanent dentitions, respectively] compared with corresponding within-study estimates [h2 of 28% (95% CI: 9%: 48%) and 17% (95% CI: 2%: 31%)] or previously published estimates. This study was designed to identify common genetic variants with modest effects which are consistent across different populations. We found few single variants associated with caries status under these assumptions. Phenotypic heterogeneity between cohorts and limited statistical power will have contributed; these findings could also reflect complexity not captured by our study design, such as genetic effects which are conditional on environmental exposure.

AB - Prior studies suggest dental caries traits in children and adolescents are partially heritable, but there has been no large-scale consortium genome-wide association study (GWAS) to date. We therefore performed GWAS for caries in participants aged 2.5-18.0 years from nine contributing centres. Phenotype definitions were created for the presence or absence of treated or untreated caries, stratified by primary and permanent dentition. All studies tested for association between caries and genotype dosage and the results were combined using fixed-effects meta-analysis. Analysis included up to 19 003 individuals (7530 affected) for primary teeth and 13 353 individuals (5875 affected) for permanent teeth. Evidence for association with caries status was observed at rs1594318-C for primary teeth [intronic within ALLC, odds ratio (OR) 0.85, effect allele frequency (EAF) 0.60, P 4.13e-8] and rs7738851-A (intronic within NEDD9, OR 1.28, EAF 0.85, P 1.63e-8) for permanent teeth. Consortium-wide estimated heritability of caries was low [h2 of 1% (95% CI: 0%: 7%) and 6% (95% CI 0%: 13%) for primary and permanent dentitions, respectively] compared with corresponding within-study estimates [h2 of 28% (95% CI: 9%: 48%) and 17% (95% CI: 2%: 31%)] or previously published estimates. This study was designed to identify common genetic variants with modest effects which are consistent across different populations. We found few single variants associated with caries status under these assumptions. Phenotypic heterogeneity between cohorts and limited statistical power will have contributed; these findings could also reflect complexity not captured by our study design, such as genetic effects which are conditional on environmental exposure.

U2 - 10.1093/hmg/ddy237

DO - 10.1093/hmg/ddy237

M3 - Journal article

VL - 27

SP - 3113

EP - 3127

JO - Human Molecular Genetics

JF - Human Molecular Genetics

SN - 0964-6906

IS - 17

ER -

ID: 55367284