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Region Hovedstaden - en del af Københavns Universitetshospital
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Consensus paper on post-operative pediatric cerebellar mutism syndrome: the Iceland Delphi results

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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  • Thora Gudrunardottir
  • Angela T Morgan
  • Andrew L Lux
  • David A Walker
  • Karin S Walsh
  • Elizabeth M Wells
  • Jeffrey H Wisoff
  • Marianne Juhler
  • Jeremy D Schmahmann
  • Robert F Keating
  • Coriene Catsman-Berrevoets
  • Iceland Delphi Group
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INTRODUCTION: Confusion has surrounded the description of post-operative mutism and associated morbidity in pediatric patients with cerebellar tumors for years. The heterogeneity of definitions and diagnostic features has hampered research progress within the field, and to date, no international guidelines exist on diagnosis, prevention, treatment, or follow-up of this debilitating condition. An international group of clinicians and researchers from multiple relevant disciplines recently formed a cohesive panel to formulate a new working definition and agree upon standardized methods for diagnosis and follow-up.

METHODS: Consensus was obtained using the modified nominal group technique, involving four rounds of online Delphi questionnaires interspersed with a structured consensus conference with lectures, group work, and open discussion sessions.

RESULTS: A new, proposed definition of "post-operative pediatric CMS" was formed, preliminary recommendations for diagnostic and follow-up procedures were created, two working groups on a new scoring scale and risk prediction and prevention were established, and areas were identified where further information is needed.

DISCUSSION: The consensus process was motivated by desire to further research and improve quality of life for pediatric brain tumor patients. The Delphi rounds identified relevant topics and established basic agreement, while face-to-face engagement helped resolve matters of conflict and refine terminology. The new definition is intended to provide a more solid foundation for future clinical and research work. It is thought as a consensus for moving forward and hopefully paves the way to developing a standard approach to this challenging problem with the advent of better scoring methods and ultimate goal of reducing the risk of CMS.

OriginalsprogEngelsk
TidsskriftChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
Vol/bind32
Udgave nummer7
Sider (fra-til)1195-203
ISSN0256-7040
DOI
StatusUdgivet - 2016

ID: 46436044