Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Consensus guidelines for the identification and treatment of biofilms in chronic nonhealing wounds

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Molecular and histological studies of bladder wound healing in a rodent model

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Non-invasive measurement of reepithelialization and microvascularity of suction-blister wounds with benchmarking to histology

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Impaired collagen synthesis in the rectum may be a molecular target in anastomotic leakage prophylaxis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Antiscarring pharmaceuticals: lost in translation?

    Publikation: Bidrag til tidsskriftLederForskningpeer review

  1. The efficacy of topical agents used in wounds for managing chronic biofilm infections: A systematic review

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The environmental occurrence of Pseudomonas aeruginosa

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Biofilms of Mycobacterium abscessus complex can be sensitized to antibiotics by disaggregation and oxygenation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Minimum information guideline for spectrofotometric and fluorometric methods to assess biofilm formation in microplates

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Is pseudarthrosis after spinal instrumentation caused by a chronic infection?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Gregory Schultz
  • Thomas Bjarnsholt
  • Garth A James
  • David J Leaper
  • Andrew J McBain
  • Matthew Malone
  • Paul Stoodley
  • Theresa Swanson
  • Masahiro Tachi
  • Randall D Wolcott
  • Global Wound Biofilm Expert Panel
Vis graf over relationer

BACKGROUND: Despite a growing consensus that biofilms contribute to a delay in the healing of chronic wounds, conflicting evidence pertaining to their identification and management can lead to uncertainty regarding treatment. This, in part, has been driven by reliance on in vitro data or animal models, which may not directly correlate to clinical evidence on the importance of biofilms. Limited data presented in human studies have further contributed to the uncertainty. Guidelines for care of chronic wounds with a focus on biofilms are needed to help aid the identification and management of biofilms, providing a clinical focus to support clinicians in improving patient care through evidence-based medicine.

METHODS: A Global Wound Biofilm Expert Panel, comprising 10 clinicians and researchers with expertise in laboratory and clinical aspects of biofilms, was identified and convened. A modified Delphi process, based on published scientific data and expert opinion, was used to develop consensus statements that could help identify and treat biofilms as part of the management of chronic nonhealing wounds. Using an electronic survey, panel members rated their agreement with statements about biofilm identification and treatment, and the management of chronic nonhealing wounds. Final consensus statements were agreed on in a face-to-face meeting.

RESULTS: Participants reached consensus on 61 statements in the following topic areas: understanding biofilms and the problems they cause clinicians; current diagnostic options; clinical indicators of biofilms; future options for diagnostic tests; treatment strategies; mechanical debridement; topical antiseptics; screening antibiofilm agents; and levels of evidence when choosing antibiofilm treatments.

CONCLUSION: This consensus document attempts to clarify misunderstandings about the role of biofilms in clinical practice, and provides a basis for clinicians to recognize biofilms in chronic nonhealing wounds and manage patients optimally. A new paradigm for wound care, based on a stepped-down treatment approach, was derived from the consensus statements.

OriginalsprogEngelsk
TidsskriftWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Vol/bind25
Udgave nummer5
Sider (fra-til)744-757
Antal sider14
ISSN1067-1927
DOI
StatusUdgivet - sep. 2017

ID: 52705666