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Congenital cerebral palsy and prenatal exposure to self-reported maternal infections, fever, or smoking

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Streja, E, Miller, J, Bech, BH, Greene, N, Pedersen, LH, Yeargin-Allsopp, M, Van Naarden Braun, K, Schendel, DE, Christensen, D, Uldall, P & Olsen, J 2013, 'Congenital cerebral palsy and prenatal exposure to self-reported maternal infections, fever, or smoking' American Journal of Obstetrics and Gynecology, bind 209, nr. 4, s. 332.e1-332.e10. https://doi.org/10.1016/j.ajog.2013.06.023

APA

CBE

Streja E, Miller J, Bech BH, Greene N, Pedersen LH, Yeargin-Allsopp M, Van Naarden Braun K, Schendel DE, Christensen D, Uldall P, Olsen J. 2013. Congenital cerebral palsy and prenatal exposure to self-reported maternal infections, fever, or smoking. American Journal of Obstetrics and Gynecology. 209(4):332.e1-332.e10. https://doi.org/10.1016/j.ajog.2013.06.023

MLA

Vancouver

Author

Streja, Elani ; Miller, Jessica ; Bech, Bodil H ; Greene, Naomi ; Pedersen, Lars Henning ; Yeargin-Allsopp, Marshalyn ; Van Naarden Braun, Kim ; Schendel, Diana E ; Christensen, Deborah ; Uldall, Peter ; Olsen, Jørn. / Congenital cerebral palsy and prenatal exposure to self-reported maternal infections, fever, or smoking. I: American Journal of Obstetrics and Gynecology. 2013 ; Bind 209, Nr. 4. s. 332.e1-332.e10.

Bibtex

@article{fd65ffef651c4813b717fbb6977795d1,
title = "Congenital cerebral palsy and prenatal exposure to self-reported maternal infections, fever, or smoking",
abstract = "OBJECTIVE: The objective of the study was to investigate the association between maternal self-reported infections, fever, and smoking in the prenatal period and the subsequent risk for congenital cerebral palsy (CP).STUDY DESIGN: We included the 81,066 mothers of singletons born between 1996 and 2003 who participated in the Danish National Birth Cohort. Children were followed up through December 2008. Information on maternal infections, fever, smoking, and other demographic and lifestyle factors during pregnancy were reported by mothers in computer-assisted telephone interviews in early and midgestation. We identified 139 CP cases including 121 cases of spastic CP (sCP) as confirmed by the Danish National Cerebral Palsy Register. Cox proportional hazards regression models were used to estimate adjusted hazard ratios (aHRs) and 95{\%} confidence intervals (CIs).RESULTS: Self-reported vaginal infections were associated with an increased risk of CP and sCP (aHR, 1.52; 95{\%} CI, 1.04-2.24; and aHR, 1.73; 95{\%} CI, 1.16-2.60, respectively) and particularly untreated vaginal infections were associated with an increased risk of sCP (aHR, 1.95; 95{\%} CI, 1.16-3.26). Fever was associated with the risk of CP (aHR, 1.53; 95{\%} CI, 1.06-2.21). Smoking 10 or more cigarettes per day during pregnancy was also associated with sCP (aHR, 1.80; 95{\%} CI, 1.10-2.94). There was a modest excess in risk for children exposed to both heavy smoking and vaginal infections. No other self-reported infections were significantly associated with CP.CONCLUSION: Self-reported vaginal infections, fever, and smoking 10 or more cigarettes per day during pregnancy were associated with a higher risk of overall CP and/or sCP.",
keywords = "Adolescent, Adult, Cerebral Palsy, Child, Child, Preschool, Cohort Studies, Denmark, Female, Fever, Herpes Genitalis, Herpes Labialis, Humans, Infant, Muscle Spasticity, Pregnancy, Pregnancy Complications, Infectious, Prenatal Exposure Delayed Effects, Proportional Hazards Models, Smoking, Urinary Tract Infections, Vaginitis, Young Adult",
author = "Elani Streja and Jessica Miller and Bech, {Bodil H} and Naomi Greene and Pedersen, {Lars Henning} and Marshalyn Yeargin-Allsopp and {Van Naarden Braun}, Kim and Schendel, {Diana E} and Deborah Christensen and Peter Uldall and J{\o}rn Olsen",
note = "Copyright {\circledC} 2013 Mosby, Inc. All rights reserved.",
year = "2013",
month = "10",
doi = "10.1016/j.ajog.2013.06.023",
language = "English",
volume = "209",
pages = "332.e1--332.e10",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby, Inc",
number = "4",

}

RIS

TY - JOUR

T1 - Congenital cerebral palsy and prenatal exposure to self-reported maternal infections, fever, or smoking

AU - Streja, Elani

AU - Miller, Jessica

AU - Bech, Bodil H

AU - Greene, Naomi

AU - Pedersen, Lars Henning

AU - Yeargin-Allsopp, Marshalyn

AU - Van Naarden Braun, Kim

AU - Schendel, Diana E

AU - Christensen, Deborah

AU - Uldall, Peter

AU - Olsen, Jørn

N1 - Copyright © 2013 Mosby, Inc. All rights reserved.

PY - 2013/10

Y1 - 2013/10

N2 - OBJECTIVE: The objective of the study was to investigate the association between maternal self-reported infections, fever, and smoking in the prenatal period and the subsequent risk for congenital cerebral palsy (CP).STUDY DESIGN: We included the 81,066 mothers of singletons born between 1996 and 2003 who participated in the Danish National Birth Cohort. Children were followed up through December 2008. Information on maternal infections, fever, smoking, and other demographic and lifestyle factors during pregnancy were reported by mothers in computer-assisted telephone interviews in early and midgestation. We identified 139 CP cases including 121 cases of spastic CP (sCP) as confirmed by the Danish National Cerebral Palsy Register. Cox proportional hazards regression models were used to estimate adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs).RESULTS: Self-reported vaginal infections were associated with an increased risk of CP and sCP (aHR, 1.52; 95% CI, 1.04-2.24; and aHR, 1.73; 95% CI, 1.16-2.60, respectively) and particularly untreated vaginal infections were associated with an increased risk of sCP (aHR, 1.95; 95% CI, 1.16-3.26). Fever was associated with the risk of CP (aHR, 1.53; 95% CI, 1.06-2.21). Smoking 10 or more cigarettes per day during pregnancy was also associated with sCP (aHR, 1.80; 95% CI, 1.10-2.94). There was a modest excess in risk for children exposed to both heavy smoking and vaginal infections. No other self-reported infections were significantly associated with CP.CONCLUSION: Self-reported vaginal infections, fever, and smoking 10 or more cigarettes per day during pregnancy were associated with a higher risk of overall CP and/or sCP.

AB - OBJECTIVE: The objective of the study was to investigate the association between maternal self-reported infections, fever, and smoking in the prenatal period and the subsequent risk for congenital cerebral palsy (CP).STUDY DESIGN: We included the 81,066 mothers of singletons born between 1996 and 2003 who participated in the Danish National Birth Cohort. Children were followed up through December 2008. Information on maternal infections, fever, smoking, and other demographic and lifestyle factors during pregnancy were reported by mothers in computer-assisted telephone interviews in early and midgestation. We identified 139 CP cases including 121 cases of spastic CP (sCP) as confirmed by the Danish National Cerebral Palsy Register. Cox proportional hazards regression models were used to estimate adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs).RESULTS: Self-reported vaginal infections were associated with an increased risk of CP and sCP (aHR, 1.52; 95% CI, 1.04-2.24; and aHR, 1.73; 95% CI, 1.16-2.60, respectively) and particularly untreated vaginal infections were associated with an increased risk of sCP (aHR, 1.95; 95% CI, 1.16-3.26). Fever was associated with the risk of CP (aHR, 1.53; 95% CI, 1.06-2.21). Smoking 10 or more cigarettes per day during pregnancy was also associated with sCP (aHR, 1.80; 95% CI, 1.10-2.94). There was a modest excess in risk for children exposed to both heavy smoking and vaginal infections. No other self-reported infections were significantly associated with CP.CONCLUSION: Self-reported vaginal infections, fever, and smoking 10 or more cigarettes per day during pregnancy were associated with a higher risk of overall CP and/or sCP.

KW - Adolescent

KW - Adult

KW - Cerebral Palsy

KW - Child

KW - Child, Preschool

KW - Cohort Studies

KW - Denmark

KW - Female

KW - Fever

KW - Herpes Genitalis

KW - Herpes Labialis

KW - Humans

KW - Infant

KW - Muscle Spasticity

KW - Pregnancy

KW - Pregnancy Complications, Infectious

KW - Prenatal Exposure Delayed Effects

KW - Proportional Hazards Models

KW - Smoking

KW - Urinary Tract Infections

KW - Vaginitis

KW - Young Adult

U2 - 10.1016/j.ajog.2013.06.023

DO - 10.1016/j.ajog.2013.06.023

M3 - Journal article

VL - 209

SP - 332.e1-332.e10

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 4

ER -

ID: 43624967