Confirmation of novel type 1 diabetes risk loci in families

J D Cooper, J M M Howson, D Smyth, N M Walker, Hanne Stevens, Jian Yang, J-X She, G S Eisenbarth, M Rewers, J A Todd, B Akolkar, P Concannon, H A Erlich, C Julier, G Morahan, Jørn Nerup, C Nierras, F Pociot, Steve Rich, Type 1 Diabetes Genetics Consortium

    50 Citationer (Scopus)

    Abstract

    Over 50 regions of the genome have been associated with type 1 diabetes risk, mainly using large case/control collections. In a recent genome-wide association (GWA) study, 18 novel susceptibility loci were identified and replicated, including replication evidence from 2,319 families. Here, we, the Type 1 Diabetes Genetics Consortium (T1DGC), aimed to exclude the possibility that any of the 18 loci were false-positives due to population stratification by significantly increasing the statistical power of our family study.
    OriginalsprogEngelsk
    TidsskriftDiabetologia
    Vol/bind55
    Udgave nummer4
    Sider (fra-til)996-1000
    Antal sider5
    ISSN0012-186X
    DOI
    StatusUdgivet - apr. 2012

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