Confirmation of novel type 1 diabetes risk loci in families

J D Cooper; J M M Howson; D Smyth; N M Walker; Hanne Stevens; Jian Yang; J-X She; G S Eisenbarth; M Rewers; J A Todd; B Akolkar; P Concannon; H A Erlich; C Julier; G Morahan; Jørn Nerup; C Nierras; F Pociot; Steve Rich; Type 1 Diabetes Genetics Consortium

doi:10.1007/s00125-012-2450-3

Confirmation of novel type 1 diabetes risk loci in families

J D Cooper
, J M M Howson
, D Smyth
, N M Walker
, Hanne Stevens
, Jian Yang
, J-X She
, G S Eisenbarth
, M Rewers
, J A Todd
, B Akolkar
, P Concannon
, H A Erlich
, C Julier
, G Morahan
, Jørn Nerup
, C Nierras
, F Pociot
, Steve Rich
, Type 1 Diabetes Genetics Consortium

51 Citationer (Scopus)

Abstract

Over 50 regions of the genome have been associated with type 1 diabetes risk, mainly using large case/control collections. In a recent genome-wide association (GWA) study, 18 novel susceptibility loci were identified and replicated, including replication evidence from 2,319 families. Here, we, the Type 1 Diabetes Genetics Consortium (T1DGC), aimed to exclude the possibility that any of the 18 loci were false-positives due to population stratification by significantly increasing the statistical power of our family study.

Originalsprog	Engelsk
Tidsskrift	Diabetologia
Vol/bind	55
Udgave nummer	4
Sider (fra-til)	996-1000
Antal sider	5
ISSN	0012-186X
DOI	https://doi.org/10.1007/s00125-012-2450-3
Status	Udgivet - apr. 2012

Adgang til dokumentet

10.1007/s00125-012-2450-3

Citationsformater

Cooper, J. D., Howson, J. M. M., Smyth, D., Walker, N. M., Stevens, H., Yang, J., She, J.-X., Eisenbarth, G. S., Rewers, M., Todd, J. A., Akolkar, B., Concannon, P., Erlich, H. A., Julier, C., Morahan, G., Nerup, J., Nierras, C., Pociot, F., Rich, S., & Type 1 Diabetes Genetics Consortium (2012). Confirmation of novel type 1 diabetes risk loci in families. Diabetologia, 55(4), 996-1000. https://doi.org/10.1007/s00125-012-2450-3

Cooper, JD, Howson, JMM, Smyth, D, Walker, NM, Stevens, H, Yang, J, She, J-X, Eisenbarth, GS, Rewers, M, Todd, JA, Akolkar, B, Concannon, P, Erlich, HA, Julier, C, Morahan, G, Nerup, J, Nierras, C, Pociot, F, Rich, S & Type 1 Diabetes Genetics Consortium 2012, 'Confirmation of novel type 1 diabetes risk loci in families', Diabetologia, bind 55, nr. 4, s. 996-1000. https://doi.org/10.1007/s00125-012-2450-3

@article{85cdb0e3a2814d06bf0853a8f46ebf1c,

title = "Confirmation of novel type 1 diabetes risk loci in families",

abstract = "Over 50 regions of the genome have been associated with type 1 diabetes risk, mainly using large case/control collections. In a recent genome-wide association (GWA) study, 18 novel susceptibility loci were identified and replicated, including replication evidence from 2,319 families. Here, we, the Type 1 Diabetes Genetics Consortium (T1DGC), aimed to exclude the possibility that any of the 18 loci were false-positives due to population stratification by significantly increasing the statistical power of our family study.",

keywords = "Diabetes Mellitus, Type 1, European Continental Ancestry Group, Genetic Loci, Genetic Predisposition to Disease, Genotype, Humans, Polymorphism, Single Nucleotide",

author = "Cooper, \{J D\} and Howson, \{J M M\} and D Smyth and Walker, \{N M\} and Hanne Stevens and Jian Yang and J-X She and Eisenbarth, \{G S\} and M Rewers and Todd, \{J A\} and B Akolkar and P Concannon and Erlich, \{H A\} and C Julier and G Morahan and J{\o}rn Nerup and C Nierras and F Pociot and Steve Rich and \{Type 1 Diabetes Genetics Consortium\}",

year = "2012",

month = apr,

doi = "10.1007/s00125-012-2450-3",

language = "English",

volume = "55",

pages = "996--1000",

journal = "Diabetologia",

issn = "0012-186X",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "4",

}

TY - JOUR

T1 - Confirmation of novel type 1 diabetes risk loci in families

AU - Cooper, J D

AU - Howson, J M M

AU - Smyth, D

AU - Walker, N M

AU - Stevens, Hanne

AU - Yang, Jian

AU - She, J-X

AU - Eisenbarth, G S

AU - Rewers, M

AU - Todd, J A

AU - Akolkar, B

AU - Concannon, P

AU - Erlich, H A

AU - Julier, C

AU - Morahan, G

AU - Nerup, Jørn

AU - Nierras, C

AU - Pociot, F

AU - Rich, Steve

AU - Type 1 Diabetes Genetics Consortium

PY - 2012/4

Y1 - 2012/4

N2 - Over 50 regions of the genome have been associated with type 1 diabetes risk, mainly using large case/control collections. In a recent genome-wide association (GWA) study, 18 novel susceptibility loci were identified and replicated, including replication evidence from 2,319 families. Here, we, the Type 1 Diabetes Genetics Consortium (T1DGC), aimed to exclude the possibility that any of the 18 loci were false-positives due to population stratification by significantly increasing the statistical power of our family study.

AB - Over 50 regions of the genome have been associated with type 1 diabetes risk, mainly using large case/control collections. In a recent genome-wide association (GWA) study, 18 novel susceptibility loci were identified and replicated, including replication evidence from 2,319 families. Here, we, the Type 1 Diabetes Genetics Consortium (T1DGC), aimed to exclude the possibility that any of the 18 loci were false-positives due to population stratification by significantly increasing the statistical power of our family study.

KW - Diabetes Mellitus, Type 1

KW - European Continental Ancestry Group

KW - Genetic Loci

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Humans

KW - Polymorphism, Single Nucleotide

U2 - 10.1007/s00125-012-2450-3

DO - 10.1007/s00125-012-2450-3

M3 - Journal article

C2 - 22278338

SN - 0012-186X

VL - 55

SP - 996

EP - 1000

JO - Diabetologia

JF - Diabetologia

IS - 4

ER -

Confirmation of novel type 1 diabetes risk loci in families

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater