Cone photoreceptor density in the Copenhagen Child Cohort at age 16-17 years

Christina Eckmann-Hansen, Mathias Hvidtfelt Hansen, Poul Pedersen Laigaard, Birgit Agnes Sander, Inger Christine Munch, Else Marie Olsen, Anne Mette Skovgaard, Michael Larsen


PURPOSE: To examine cone density in relation to gestational and morphological parameters in the Copenhagen Child Cohort (CCC2000).

METHODS: The macula was imaged using adaptive optics in 1,296 adolescents aged 16-17 years. Axial length and distance visual acuity were determined. Absolute and angular cone photoreceptor density were analysed for an 80 × 80-pixel area, 2 degrees temporal to the fovea. Association with axial length was analysed with linear regression. Correlation with visual acuity was described with a Pearson correlation coefficient. Associations of cone density with gestational parameters, maternal smoking, sex and age were analysed using multiple regression adjusted for axial length.

RESULTS: Mean absolute cone density was 30,007 cones/mm2 (SD ± 3,802) and mean angular cone density was 2,383 cones/deg2 (SD ± 231). Peri- and postnatal parameters, sex and age had no statistically significant effect on cone density (p > 0.05). Absolute cone density decreased with longer axial length (-2,855 cones/mm2 per mm or -9.7% per mm, p < 0.0001). For angular density, which included a correction for the geometrical enlargement of the eye with axial length, a decrease with axial length was detectable, but it was small (-20 cones/deg2 per mm or -0.84% per mm, p = 0.009).

CONCLUSIONS: The decrease in cone density per unit solid angle with increasing axial length was small, less than 1 percent per mm, indicating that expansion of the posterior pole during the development of refraction takes place without a clinically significant loss of cones. Perinatal parameters, within the spectrum presented by the study population, had no detectable effect on cone density.

TidsskriftOphthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)
Udgave nummer6
Sider (fra-til)1292-1299
Antal sider8
StatusUdgivet - nov. 2021


Dyk ned i forskningsemnerne om 'Cone photoreceptor density in the Copenhagen Child Cohort at age 16-17 years'. Sammen danner de et unikt fingeraftryk.