Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Concurrent anxiety in patients with major depression and cerebral serotonin 4 receptor binding. A NeuroPharm-1 study

Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

DOI

  1. Maternal pregnancy-related infections and autism spectrum disorder-the genetic perspective

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  2. Acute and long-term effects of psilocybin on energy balance and feeding behavior in mice

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  3. Systemic DNA and RNA damage from oxidation after serotonergic treatment of unipolar depression

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  1. Trajectory of aberrant reward processing in patients with bipolar disorder - A longitudinal fMRI study

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  2. Brain serotonin transporter is associated with cognitive-affective biases in healthy individuals

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  3. Diabetes, sleep disorders and risk of depression - A Danish register-based cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  4. Acute and long-term effects of psilocybin on energy balance and feeding behavior in mice

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  5. An fMRI-compatible system for targeted electrical stimulation

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

Vis graf over relationer

Concurrent anxiety is frequent in major depressive disorder and a shared pathophysiological mechanism between anxiety and other depressive symptoms is plausible. The serotonin 4 receptor (5-HT4R) has been implicated in both depression and anxiety. This is the first study to investigate the association between the cerebral 5-HT4R binding and anxiety in patients with depression before and after antidepressant treatment and the association to treatment response. Ninety-one drug-free patients with depression were positron emission tomography scanned with the 5-HT4R ligand [11C]-SB207145. Depression severity and concurrent anxiety was measured at baseline and throughout 8 weeks of antidepressant treatment. Anxiety measures included four domains: anxiety/somatization factor score; Generalized Anxiety Disorder 10-items (GAD-10) score; anxiety/somatization factor score ≥7 (anxious depression) and syndromal anxious depression. Forty patients were rescanned at week 8. At baseline, we found a negative association between global 5-HT4R binding and both GAD-10 score (p < 0.01) and anxiety/somatization factor score (p = 0.06). Further, remitters had a higher baseline anxiety/somatization factor score compared with non-responders (p = 0.04). At rescan, patients with syndromal anxious depression had a greater change in binding relative to patients with non-syndromal depression (p = 0.04). Concurrent anxiety in patients with depression measured by GAD-10 score and anxiety/somatization factor score is negatively associated with cerebral 5-HT4R binding. A lower binding may represent a subtype with reduced natural resilience against anxiety in a depressed state, and concurrent anxiety may influence the effect on the 5-HT4R from serotonergic antidepressants. The 5-HT4R is a promising neuroreceptor for further understanding the underpinnings of concurrent anxiety in patients with depression.

OriginalsprogEngelsk
Artikelnummer273
TidsskriftTranslational psychiatry
Vol/bind12
Udgave nummer1
Sider (fra-til)273
ISSN2158-3188
DOI
StatusUdgivet - 11 jul. 2022

Bibliografisk note

© 2022. The Author(s).

ID: 79394513