Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Concentrations of the acute phase reactants high-sensitive C-reactive protein and YKL-40 and of interleukin-6 before and after treatment in patients with acromegaly and growth hormone deficiency

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Phenotypic and genotypic features of a large kindred with a germline AIP variant

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Changes in subtypes of overt thyrotoxicosis and hypothyroidism following iodine fortification

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Thyrotoxicosis after iodine fortification. A 21-year Danish population-based study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Serum chemerin levels are inversely associated with renal function in a general population

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Assessment of time to glucose peak during an oral glucose tolerance test

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  1. Semen quality in hypogonadal acromegalic patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Surgical Management, Preoperative Tumor Localization, and Histopathology of 80 Patients Operated on for Insulinoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Metabolic effects of dopamine agonists in patients with prolactinomas: a systematic review and meta-analysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Acromegaly is accompanied by increased cardiovascular mortality and a cluster of proatherogenic risk factors. In the general population, ischaemic heart disease (IHD) is associated with elevated levels of inflammatory markers. The acute phase reactant (APR) C-reactive protein (CRP) has been reported to be reduced in acromegaly and increase after treatment, suggesting that excess of GH/IGF-I could have anti-inflammatory effects. This is in accordance with results obtained in patients with growth hormone deficiency (GHD), where increased levels of CRP have been reported.

OBJECTIVE: To investigate the hypothesis that the GH/IGF-I system is a suppressive regulator of inflammatory processes.

SUBJECTS AND METHODS: Twenty-one acromegalic patients and 19 GH-deficient patients were studied. The two APRs CRP and YKL-40 and the proinflammatory cytokine interleukin-6 (IL-6) were measured before and after treatment and in healthy matched controls.

RESULTS: In acromegalic patients, serum concentrations of high-sensitive CRP (hsCRP) and YKL-40 were reduced compared to controls (P < 0.001) and increased (P < 0.001) after treatment, together with IL-6 (P = 0.021), to levels comparable with controls. Pretreatment serum YKL-40 and IL-6 showed a significant inverse correlation with IGF-I and GH. In GH-deficient patients, hsCRP and YKL-40 were elevated compared to controls (P = 0.001 and P = 0.048). During treatment, levels of both APRs showed a trend towards a decrease (P = 0.087 and P = 0.060), and after treatment, levels of YKL-40 no longer differed from that of controls. Serum IL-6 was not different from controls and did not change during GH treatment.

CONCLUSION: The results point to the possibility of a relationship between GH disturbances and inflammatory processes.

OriginalsprogEngelsk
TidsskriftClinical Endocrinology
Vol/bind67
Udgave nummer6
Sider (fra-til)909-16
Antal sider8
ISSN0300-0664
DOI
StatusUdgivet - dec. 2007

ID: 52683637