Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Concentration changes during venous occlusion of proteins with affinity for extracellular matrix in insulin-dependent diabetes mellitus A sign of vascular damage in patients with diabetic nephropathy?

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Decreased syntheses of tissue plasminogen activator antigen in users of oral contraceptives

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Isolation and characterization of gene expression in non-metastasizing versus metastasizing human breast cancer cells

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Fibrinolysis in insulin-dependent diabetic patients with and without nephropathy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Changes in Albuminuria Predict Cardiovascular and Renal Outcomes in Type 2 Diabetes: A Post Hoc Analysis of the LEADER Trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Finerenone and Cardiovascular Outcomes in Patients with Chronic Kidney Disease and Type 2 Diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Effect of Dapagliflozin on Clinical Outcomes in Patients with Chronic Kidney Disease, With and Without Cardiovascular Disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Objective: To investigate protein concentration changes during venous occlusion of proteins with reported affinity for extracellular matrix (plasminogen activator inhibitor type 1, antithrombin III, fibronectin and von Willebrand factor) in comparison with proteins with no reported affinity (albumin, tissue-type plasminogen activator, immunoglobulin G, fibrinogen, α2-macroglobulin, immunoglobulin M) in insulin-dependent diabetic patients with and without diabetic nephropathy. Design: Cross-sectional study. Setting: Outpatient diabetic clinic in a tertiary hospital. Subjects: Insulin-dependent diabetic patients without diabetic nephropathy (normoalbuminuria, n = 17), patients with incipient diabetic nephropathy (n = 19), and patients with diabetic nephropathy (n = 13). Non-diabetic subjects served as a control group (n = 14). Results: For plasminogen activator inhibitor type 1 and fibronectin we found a smaller increase in protein concentration after venous occlusion in diabetic patients with nephropathy than in patients without nephropathy (1.7 (- 3-5.8) vs 3.2 (- 0.4-8.7) ng/ml, P < 0.05; 0.01 (- 0.23-0.05) vs 0.05 (0-0.13) g/l, P < 0.01 respectively). Remarkably, von Willebrand factor showed a decrease in patients with nephropathy - 0.27 (- 0.6-0.38) vs - 0.01 (- 0.33-0.25) lU/ml, P < 0.01. Proteins with no reported affinity for extracellular matrix increased in a similar way in patients with and without nephropathy (albumin 9 (3-12) vs 10 (5-19) g/l; tissue-type plasminogen activator 3.6 (0.8-21.7) vs 4.1 (0-10.8) ng/ml; immunoglobulin G 1.9 (0.6-4.9) vs 2.6 (1.6-8.9) g/l; fibrinogen 30 (9-60) vs 34 (- 38-77)%; α2-macroglobulin 52 (- 44-102) vs 48 (- 68-90)% and immunoglobulin M 0.40 (0.11-0.78) vs 0.30 (- 0.11-0.75) g/l). The changes in protein concentration during venous occlusion did not depend on the molecular weight or charge. Conclusion: Proteins with reported affinity to extracellular matrix show a smaller increase during venous occlusion in patients with nephropathy compared with patients without nephropathy. This may reflect changes in the vascular wall in insulin-dependent diabetic patients with nephropathy.

OriginalsprogEngelsk
TidsskriftFibrinolysis
Vol/bind13
Udgave nummer3
Sider (fra-til)142-147
Antal sider6
ISSN0268-9499
DOI
StatusUdgivet - 1 jan. 1999

ID: 55724327