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Region Hovedstaden - en del af Københavns Universitetshospital
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Comparison of statistical inferences from the DerSimonian-Laird and alternative random-effects model meta-analyses - an empirical assessment of 920 Cochrane primary outcome meta-analyses

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Development of a combined database for meta-epidemiological research

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Development of a combined database for meta-epidemiological research

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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In random-effects model meta-analysis, the conventional DerSimonian-Laird (DL) estimator typically underestimates the between-trial variance. Alternative variance estimators have been proposed to address this bias. This study aims to empirically compare statistical inferences from random-effects model meta-analyses on the basis of the DL estimator and four alternative estimators, as well as distributional assumptions (normal distribution and t-distribution) about the pooled intervention effect. We evaluated the discrepancies of p-values, 95% confidence intervals (CIs) in statistically significant meta-analyses, and the degree (percentage) of statistical heterogeneity (e.g. I(2)) across 920 Cochrane primary outcome meta-analyses. In total, 414 of the 920 meta-analyses were statistically significant with the DL meta-analysis, and 506 were not. Compared with the DL estimator, the four alternative estimators yielded p-values and CIs that could be interpreted as discordant in up to 11.6% or 6% of the included meta-analyses pending whether a normal distribution or a t-distribution of the intervention effect estimates were assumed. Large discrepancies were observed for the measures of degree of heterogeneity when comparing DL with each of the four alternative estimators. Estimating the degree (percentage) of heterogeneity on the basis of less biased between-trial variance estimators seems preferable to current practice. Disclosing inferential sensitivity of p-values and CIs may also be necessary when borderline significant results have substantial impact on the conclusion. Copyright © 2012 John Wiley & Sons, Ltd.

OriginalsprogEngelsk
TidsskriftResearch Synthesis Methods
Vol/bind2
Udgave nummer4
Sider (fra-til)238-253
Antal sider16
ISSN1759-2879
DOI
StatusUdgivet - dec. 2011

ID: 36768422