Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Comparison of simultaneous arterial spin labeling MRI and 15O-H2O PET measurements of regional cerebral blood flow in rest and altered perfusion states

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. High spatiotemporal vessel-specific hemodynamic mapping with multi-echo single-vessel fMRI

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Modification of oxygen consumption and blood flow in mouse somatosensory cortex by cell-type-specific neuronal activity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Cortical microinfarcts in memory clinic patients are associated with reduced cerebral perfusion

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Different preprocessing strategies lead to different conclusions: A [11C]DASB-PET reproducibility study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Volume of hippocampal subregions and clinical improvement following electroconvulsive therapy in patients with depression

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Intradural artery dilation during experimentally induced migraine attacks

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. PET imaging of meningioma with 18F-FLT: a predictor of tumour progression

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Arterial spin labelling (ASL) is a non-invasive magnetic resonance imaging (MRI) technique that may provide fully quantitative regional cerebral blood flow (rCBF) images. However, before its application in clinical routine, ASL needs to be validated against the clinical gold standard, 15O-H2O positron emission tomography (PET). We aimed to compare the two techniques by performing simultaneous quantitative ASL-MRI and 15O-H2O-PET examinations in a hybrid PET/MRI scanner. Duplicate rCBF measurements were performed in healthy young subjects (n = 14) in rest, during hyperventilation, and after acetazolamide (post-ACZ), yielding 63 combined PET/MRI datasets in total. Average global CBF by ASL-MRI and 15O-H2O-PET was not significantly different in any state (40.0 ± 6.5 and 40.6 ± 4.1 mL/100 g/min, respectively in rest, 24.5 ± 5.1 and 23.4 ± 4.8 mL/100 g/min, respectively, during hyperventilation, and 59.1 ± 10.4 and 64.7 ± 10.0 mL/100 g/min, respectively, post-ACZ). Overall, strong correlation between the two methods was found across all states (slope = 1.01, R2 = 0.82), while the correlations within individual states and of reactivity measures were weaker, in particular in rest (R2 = 0.05, p = 0.03). Regional distribution was similar, although ASL yielded higher perfusion and absolute reactivity in highly vascularized areas. In conclusion, ASL-MRI and 15O-H2O-PET measurements of rCBF are highly correlated across different perfusion states, but with variable correlation within and between hemodynamic states, and systematic differences in regional distribution.

OriginalsprogEngelsk
TidsskriftJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Vol/bind40
Udgave nummer8
Sider (fra-til)1621-1633
Antal sider13
ISSN0271-678X
DOI
StatusUdgivet - 2020

ID: 59554200