Comparison of osteoprotegerin to traditional atherosclerotic risk factors and high-sensitivity C-reactive protein for diagnosis of atherosclerosis

Rasmus Mogelvang; Sune H Pedersen; Allan Flyvbjerg; Mette Bjerre; Allan Z Iversen; Soren Galatius; Jan Frystyk; Jan S Jensen

doi:10.1016/j.amjcard.2011.09.043

Comparison of osteoprotegerin to traditional atherosclerotic risk factors and high-sensitivity C-reactive protein for diagnosis of atherosclerosis

Rasmus Mogelvang, Sune H Pedersen, Allan Flyvbjerg, Mette Bjerre, Allan Z Iversen, Soren Galatius, Jan Frystyk, Jan S Jensen

60 Citationer (Scopus)

Abstract

Atherosclerosis is the main cause of cardiovascular disease, but the extent of atherosclerosis in individual patients is difficult to estimate. A biomarker of the atherosclerotic burden would be very valuable. The aim of the present study was to evaluate the association of plasma osteoprotegerin (OPG) to clinical and subclinical atherosclerotic disease in a large community-based, cross-sectional population study. In the Copenhagen City Heart Study, OPG concentrations were measured in 5,863 men and women. A total of 494 participants had been hospitalized for ischemic heart disease or ischemic stroke, and compared to controls, this group with clinical atherosclerosis had higher mean OPG (1,773 vs 1,337 ng/L, p

Originalsprog	Engelsk
Tidsskrift	American Journal of Cardiology
Vol/bind	109
Udgave nummer	4
Sider (fra-til)	515-20
Antal sider	6
ISSN	0002-9149
DOI	https://doi.org/10.1016/j.amjcard.2011.09.043
Status	Udgivet - 2012

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10.1016/j.amjcard.2011.09.043

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@article{cfe564d795e645c4b89ecd5c7c6b1994,

title = "Comparison of osteoprotegerin to traditional atherosclerotic risk factors and high-sensitivity C-reactive protein for diagnosis of atherosclerosis",

abstract = "Atherosclerosis is the main cause of cardiovascular disease, but the extent of atherosclerosis in individual patients is difficult to estimate. A biomarker of the atherosclerotic burden would be very valuable. The aim of the present study was to evaluate the association of plasma osteoprotegerin (OPG) to clinical and subclinical atherosclerotic disease in a large community-based, cross-sectional population study. In the Copenhagen City Heart Study, OPG concentrations were measured in 5,863 men and women. A total of 494 participants had been hospitalized for ischemic heart disease or ischemic stroke, and compared to controls, this group with clinical atherosclerosis had higher mean OPG (1,773 vs 1,337 ng/L, p ",

keywords = "Adult, Aged, Aged, 80 and over, Ankle Brachial Index, Atherosclerosis, Biological Markers, C-Reactive Protein, Case-Control Studies, Cross-Sectional Studies, Diabetes Mellitus, Female, Humans, Hypercholesterolemia, Hypertension, Male, Middle Aged, Multivariate Analysis, Osteoprotegerin, Risk Factors, Smoking, Young Adult",

author = "Rasmus Mogelvang and Pedersen, {Sune H} and Allan Flyvbjerg and Mette Bjerre and Iversen, {Allan Z} and Soren Galatius and Jan Frystyk and Jensen, {Jan S}",

year = "2012",

doi = "10.1016/j.amjcard.2011.09.043",

language = "English",

volume = "109",

pages = "515--20",

journal = "American Journal of Cardiology",

issn = "0002-9149",

publisher = "Elsevier Inc.",

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TY - JOUR

T1 - Comparison of osteoprotegerin to traditional atherosclerotic risk factors and high-sensitivity C-reactive protein for diagnosis of atherosclerosis

AU - Mogelvang, Rasmus

AU - Pedersen, Sune H

AU - Flyvbjerg, Allan

AU - Bjerre, Mette

AU - Iversen, Allan Z

AU - Galatius, Soren

AU - Frystyk, Jan

AU - Jensen, Jan S

PY - 2012

Y1 - 2012

N2 - Atherosclerosis is the main cause of cardiovascular disease, but the extent of atherosclerosis in individual patients is difficult to estimate. A biomarker of the atherosclerotic burden would be very valuable. The aim of the present study was to evaluate the association of plasma osteoprotegerin (OPG) to clinical and subclinical atherosclerotic disease in a large community-based, cross-sectional population study. In the Copenhagen City Heart Study, OPG concentrations were measured in 5,863 men and women. A total of 494 participants had been hospitalized for ischemic heart disease or ischemic stroke, and compared to controls, this group with clinical atherosclerosis had higher mean OPG (1,773 vs 1,337 ng/L, p

AB - Atherosclerosis is the main cause of cardiovascular disease, but the extent of atherosclerosis in individual patients is difficult to estimate. A biomarker of the atherosclerotic burden would be very valuable. The aim of the present study was to evaluate the association of plasma osteoprotegerin (OPG) to clinical and subclinical atherosclerotic disease in a large community-based, cross-sectional population study. In the Copenhagen City Heart Study, OPG concentrations were measured in 5,863 men and women. A total of 494 participants had been hospitalized for ischemic heart disease or ischemic stroke, and compared to controls, this group with clinical atherosclerosis had higher mean OPG (1,773 vs 1,337 ng/L, p

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Ankle Brachial Index

KW - Atherosclerosis

KW - Biological Markers

KW - C-Reactive Protein

KW - Case-Control Studies

KW - Cross-Sectional Studies

KW - Diabetes Mellitus

KW - Female

KW - Humans

KW - Hypercholesterolemia

KW - Hypertension

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Osteoprotegerin

KW - Risk Factors

KW - Smoking

KW - Young Adult

U2 - 10.1016/j.amjcard.2011.09.043

DO - 10.1016/j.amjcard.2011.09.043

M3 - Journal article

C2 - 22100028

SN - 0002-9149

VL - 109

SP - 515

EP - 520

JO - American Journal of Cardiology

JF - American Journal of Cardiology

IS - 4

ER -

Comparison of osteoprotegerin to traditional atherosclerotic risk factors and high-sensitivity C-reactive protein for diagnosis of atherosclerosis

Abstract

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