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Comparison of nonexposed and exposed bisphosphonate-induced osteonecrosis of the jaws: a retrospective analysis from the Copenhagen cohort and a proposal for an updated classification system

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@article{121be2a8b3184605b298ce3ecdf4c560,
title = "Comparison of nonexposed and exposed bisphosphonate-induced osteonecrosis of the jaws: a retrospective analysis from the Copenhagen cohort and a proposal for an updated classification system",
abstract = "OBJECTIVE: Nonexposed osteonecrosis of the jaws (NE-ONJ) does not fit into the current definition of osteonecrosis, which requires exposed bone. A modification of the classification of bisphosphonate-induced osteonecrosis of the jaws (ONJ) is proposed. This study aimed to test proposed criteria for NE-ONJ and compare NE-ONJ with exposed ONJ (E-ONJ) in a retrospective analysis.STUDY DESIGN: In 102 patients with E-ONJ diagnosed according to Ruggiero et al. (2006, 2009), criteria for NE-ONJ were developed. Subgroups of NE-ONJ and E-ONJ were tested against each other using nonparametric and parametric statistics.RESULTS: Among 102 patients with ONJ, 14 had NE-ONJ and 88 had E-ONJ. NE-ONJ and E-ONJ were similar in all important data (P > .05) except bone exposure.CONCLUSIONS: NE-ONJ belongs to the same disease condition as E-ONJ. NE-ONJ may be otherwise classified as ONJ stage 1, 2, or 3 and is different from ONJ stage 0. We propose to include the criteria for NE-ONJ into the classification.",
keywords = "Adult, Aged, Aged, 80 and over, Bisphosphonate-Associated Osteonecrosis of the Jaw, Denmark, Female, Humans, Male, Middle Aged, Retrospective Studies, Risk Factors",
author = "Morten Schiodt and Jesper Reibel and Peter Oturai and Thomas Kofod",
note = "Copyright {\textcopyright} 2014 Elsevier Inc. All rights reserved.",
year = "2014",
month = feb,
doi = "10.1016/j.oooo.2013.10.010",
language = "English",
volume = "117",
pages = "204--13",
journal = "Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics",
issn = "2212-4403",
publisher = "Mosby, Inc",
number = "2",

}

RIS

TY - JOUR

T1 - Comparison of nonexposed and exposed bisphosphonate-induced osteonecrosis of the jaws

T2 - a retrospective analysis from the Copenhagen cohort and a proposal for an updated classification system

AU - Schiodt, Morten

AU - Reibel, Jesper

AU - Oturai, Peter

AU - Kofod, Thomas

N1 - Copyright © 2014 Elsevier Inc. All rights reserved.

PY - 2014/2

Y1 - 2014/2

N2 - OBJECTIVE: Nonexposed osteonecrosis of the jaws (NE-ONJ) does not fit into the current definition of osteonecrosis, which requires exposed bone. A modification of the classification of bisphosphonate-induced osteonecrosis of the jaws (ONJ) is proposed. This study aimed to test proposed criteria for NE-ONJ and compare NE-ONJ with exposed ONJ (E-ONJ) in a retrospective analysis.STUDY DESIGN: In 102 patients with E-ONJ diagnosed according to Ruggiero et al. (2006, 2009), criteria for NE-ONJ were developed. Subgroups of NE-ONJ and E-ONJ were tested against each other using nonparametric and parametric statistics.RESULTS: Among 102 patients with ONJ, 14 had NE-ONJ and 88 had E-ONJ. NE-ONJ and E-ONJ were similar in all important data (P > .05) except bone exposure.CONCLUSIONS: NE-ONJ belongs to the same disease condition as E-ONJ. NE-ONJ may be otherwise classified as ONJ stage 1, 2, or 3 and is different from ONJ stage 0. We propose to include the criteria for NE-ONJ into the classification.

AB - OBJECTIVE: Nonexposed osteonecrosis of the jaws (NE-ONJ) does not fit into the current definition of osteonecrosis, which requires exposed bone. A modification of the classification of bisphosphonate-induced osteonecrosis of the jaws (ONJ) is proposed. This study aimed to test proposed criteria for NE-ONJ and compare NE-ONJ with exposed ONJ (E-ONJ) in a retrospective analysis.STUDY DESIGN: In 102 patients with E-ONJ diagnosed according to Ruggiero et al. (2006, 2009), criteria for NE-ONJ were developed. Subgroups of NE-ONJ and E-ONJ were tested against each other using nonparametric and parametric statistics.RESULTS: Among 102 patients with ONJ, 14 had NE-ONJ and 88 had E-ONJ. NE-ONJ and E-ONJ were similar in all important data (P > .05) except bone exposure.CONCLUSIONS: NE-ONJ belongs to the same disease condition as E-ONJ. NE-ONJ may be otherwise classified as ONJ stage 1, 2, or 3 and is different from ONJ stage 0. We propose to include the criteria for NE-ONJ into the classification.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Bisphosphonate-Associated Osteonecrosis of the Jaw

KW - Denmark

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Retrospective Studies

KW - Risk Factors

U2 - 10.1016/j.oooo.2013.10.010

DO - 10.1016/j.oooo.2013.10.010

M3 - Journal article

C2 - 24332520

VL - 117

SP - 204

EP - 213

JO - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics

JF - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics

SN - 2212-4403

IS - 2

ER -

ID: 44953316