Comparison of nonexposed and exposed bisphosphonate-induced osteonecrosis of the jaws: a retrospective analysis from the Copenhagen cohort and a proposal for an updated classification system

Morten Schiodt; Jesper Reibel; Peter Oturai; Thomas Kofod

doi:10.1016/j.oooo.2013.10.010

Comparison of nonexposed and exposed bisphosphonate-induced osteonecrosis of the jaws: a retrospective analysis from the Copenhagen cohort and a proposal for an updated classification system

Morten Schiodt, Jesper Reibel, Peter Oturai, Thomas Kofod

78 Citationer (Scopus)

Abstract

OBJECTIVE: Nonexposed osteonecrosis of the jaws (NE-ONJ) does not fit into the current definition of osteonecrosis, which requires exposed bone. A modification of the classification of bisphosphonate-induced osteonecrosis of the jaws (ONJ) is proposed. This study aimed to test proposed criteria for NE-ONJ and compare NE-ONJ with exposed ONJ (E-ONJ) in a retrospective analysis.

STUDY DESIGN: In 102 patients with E-ONJ diagnosed according to Ruggiero et al. (2006, 2009), criteria for NE-ONJ were developed. Subgroups of NE-ONJ and E-ONJ were tested against each other using nonparametric and parametric statistics.

RESULTS: Among 102 patients with ONJ, 14 had NE-ONJ and 88 had E-ONJ. NE-ONJ and E-ONJ were similar in all important data (P > .05) except bone exposure.

CONCLUSIONS: NE-ONJ belongs to the same disease condition as E-ONJ. NE-ONJ may be otherwise classified as ONJ stage 1, 2, or 3 and is different from ONJ stage 0. We propose to include the criteria for NE-ONJ into the classification.

Originalsprog	Engelsk
Tidsskrift	Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Vol/bind	117
Udgave nummer	2
Sider (fra-til)	204-13
Antal sider	10
ISSN	1079-2104
DOI	https://doi.org/10.1016/j.oooo.2013.10.010
Status	Udgivet - feb. 2014

Adgang til dokumentet

10.1016/j.oooo.2013.10.010

Citationsformater

Schiodt, M., Reibel, J., Oturai, P., & Kofod, T. (2014). Comparison of nonexposed and exposed bisphosphonate-induced osteonecrosis of the jaws: a retrospective analysis from the Copenhagen cohort and a proposal for an updated classification system. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 117(2), 204-13. https://doi.org/10.1016/j.oooo.2013.10.010

Comparison of nonexposed and exposed bisphosphonate-induced osteonecrosis of the jaws: a retrospective analysis from the Copenhagen cohort and a proposal for an updated classification system. / Schiodt, Morten; Reibel, Jesper; Oturai, Peter et al.
I: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Bind 117, Nr. 2, 02.2014, s. 204-13.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Schiodt, M, Reibel, J, Oturai, P & Kofod, T 2014, 'Comparison of nonexposed and exposed bisphosphonate-induced osteonecrosis of the jaws: a retrospective analysis from the Copenhagen cohort and a proposal for an updated classification system', Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, bind 117, nr. 2, s. 204-13. https://doi.org/10.1016/j.oooo.2013.10.010

@article{121be2a8b3184605b298ce3ecdf4c560,

title = "Comparison of nonexposed and exposed bisphosphonate-induced osteonecrosis of the jaws: a retrospective analysis from the Copenhagen cohort and a proposal for an updated classification system",

abstract = "OBJECTIVE: Nonexposed osteonecrosis of the jaws (NE-ONJ) does not fit into the current definition of osteonecrosis, which requires exposed bone. A modification of the classification of bisphosphonate-induced osteonecrosis of the jaws (ONJ) is proposed. This study aimed to test proposed criteria for NE-ONJ and compare NE-ONJ with exposed ONJ (E-ONJ) in a retrospective analysis.STUDY DESIGN: In 102 patients with E-ONJ diagnosed according to Ruggiero et al. (2006, 2009), criteria for NE-ONJ were developed. Subgroups of NE-ONJ and E-ONJ were tested against each other using nonparametric and parametric statistics.RESULTS: Among 102 patients with ONJ, 14 had NE-ONJ and 88 had E-ONJ. NE-ONJ and E-ONJ were similar in all important data (P > .05) except bone exposure.CONCLUSIONS: NE-ONJ belongs to the same disease condition as E-ONJ. NE-ONJ may be otherwise classified as ONJ stage 1, 2, or 3 and is different from ONJ stage 0. We propose to include the criteria for NE-ONJ into the classification.",

keywords = "Adult, Aged, Aged, 80 and over, Bisphosphonate-Associated Osteonecrosis of the Jaw, Denmark, Female, Humans, Male, Middle Aged, Retrospective Studies, Risk Factors",

author = "Morten Schiodt and Jesper Reibel and Peter Oturai and Thomas Kofod",

year = "2014",

month = feb,

doi = "10.1016/j.oooo.2013.10.010",

language = "English",

volume = "117",

pages = "204--13",

journal = "Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology",

issn = "1079-2104",

publisher = "Elsevier Inc.",

number = "2",

}

TY - JOUR

T1 - Comparison of nonexposed and exposed bisphosphonate-induced osteonecrosis of the jaws

T2 - a retrospective analysis from the Copenhagen cohort and a proposal for an updated classification system

AU - Schiodt, Morten

AU - Reibel, Jesper

AU - Oturai, Peter

AU - Kofod, Thomas

PY - 2014/2

Y1 - 2014/2

N2 - OBJECTIVE: Nonexposed osteonecrosis of the jaws (NE-ONJ) does not fit into the current definition of osteonecrosis, which requires exposed bone. A modification of the classification of bisphosphonate-induced osteonecrosis of the jaws (ONJ) is proposed. This study aimed to test proposed criteria for NE-ONJ and compare NE-ONJ with exposed ONJ (E-ONJ) in a retrospective analysis.STUDY DESIGN: In 102 patients with E-ONJ diagnosed according to Ruggiero et al. (2006, 2009), criteria for NE-ONJ were developed. Subgroups of NE-ONJ and E-ONJ were tested against each other using nonparametric and parametric statistics.RESULTS: Among 102 patients with ONJ, 14 had NE-ONJ and 88 had E-ONJ. NE-ONJ and E-ONJ were similar in all important data (P > .05) except bone exposure.CONCLUSIONS: NE-ONJ belongs to the same disease condition as E-ONJ. NE-ONJ may be otherwise classified as ONJ stage 1, 2, or 3 and is different from ONJ stage 0. We propose to include the criteria for NE-ONJ into the classification.

AB - OBJECTIVE: Nonexposed osteonecrosis of the jaws (NE-ONJ) does not fit into the current definition of osteonecrosis, which requires exposed bone. A modification of the classification of bisphosphonate-induced osteonecrosis of the jaws (ONJ) is proposed. This study aimed to test proposed criteria for NE-ONJ and compare NE-ONJ with exposed ONJ (E-ONJ) in a retrospective analysis.STUDY DESIGN: In 102 patients with E-ONJ diagnosed according to Ruggiero et al. (2006, 2009), criteria for NE-ONJ were developed. Subgroups of NE-ONJ and E-ONJ were tested against each other using nonparametric and parametric statistics.RESULTS: Among 102 patients with ONJ, 14 had NE-ONJ and 88 had E-ONJ. NE-ONJ and E-ONJ were similar in all important data (P > .05) except bone exposure.CONCLUSIONS: NE-ONJ belongs to the same disease condition as E-ONJ. NE-ONJ may be otherwise classified as ONJ stage 1, 2, or 3 and is different from ONJ stage 0. We propose to include the criteria for NE-ONJ into the classification.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Bisphosphonate-Associated Osteonecrosis of the Jaw

KW - Denmark

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Retrospective Studies

KW - Risk Factors

U2 - 10.1016/j.oooo.2013.10.010

DO - 10.1016/j.oooo.2013.10.010

M3 - Journal article

C2 - 24332520

SN - 1079-2104

VL - 117

SP - 204

EP - 213

JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

IS - 2

ER -

Comparison of nonexposed and exposed bisphosphonate-induced osteonecrosis of the jaws: a retrospective analysis from the Copenhagen cohort and a proposal for an updated classification system

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater