Comparison of histamine release in cord blood and adult blood

B W Nielsen; T M Engberg; T Bjerke; P O Schiøtz

doi:10.1007/BF01993128

Comparison of histamine release in cord blood and adult blood

B W Nielsen, T M Engberg, T Bjerke, P O Schiøtz

Abstrakt

Histamine release (HR) after stimulation with anti-IgE, concanavalin A (ConA) and Formyl-Met-Leu-Phe (FMLP) from 97 cord blood samples was compared to results obtained in identically treated blood samples from adults. The maximal HR obtained with anti-IgE did not differ significantly from the values obtained in adult blood, although a ten times higher concentration of anti-IgE was required for maximum release. Passive sensitization with IgE-rich plasma caused a significant increase in maximal anti-IgE-induced HR in the majority of cord blood samples, and the dose-response curve was similar to that obtained in adult blood. Challenge with ConA and FMLP caused a HR similar to that seen in adult blood, but the close correlation between anti-IgE- and concanavalin A-induced HR seen in adult blood was absent in cord blood.

Originalsprog	Engelsk
Tidsskrift	Agents and Actions
Vol/bind	33
Udgave nummer	1-2
Sider (fra-til)	64-6
Antal sider	3
ISSN	0065-4299
DOI	https://doi.org/10.1007/BF01993128
Status	Udgivet - maj 1991
Udgivet eksternt	Ja

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10.1007/BF01993128

Citationsformater

@article{01beeb6dd4c849849d570e091b1022e1,

title = "Comparison of histamine release in cord blood and adult blood",

abstract = "Histamine release (HR) after stimulation with anti-IgE, concanavalin A (ConA) and Formyl-Met-Leu-Phe (FMLP) from 97 cord blood samples was compared to results obtained in identically treated blood samples from adults. The maximal HR obtained with anti-IgE did not differ significantly from the values obtained in adult blood, although a ten times higher concentration of anti-IgE was required for maximum release. Passive sensitization with IgE-rich plasma caused a significant increase in maximal anti-IgE-induced HR in the majority of cord blood samples, and the dose-response curve was similar to that obtained in adult blood. Challenge with ConA and FMLP caused a HR similar to that seen in adult blood, but the close correlation between anti-IgE- and concanavalin A-induced HR seen in adult blood was absent in cord blood.",

keywords = "Aging/blood, Antibodies, Anti-Idiotypic/pharmacology, Basophils/drug effects, Concanavalin A/pharmacology, Fetal Blood/metabolism, Histamine/blood, Histamine Release/drug effects, Immunoglobulin E/immunology, N-Formylmethionine Leucyl-Phenylalanine/pharmacology",

author = "Nielsen, {B W} and Engberg, {T M} and T Bjerke and Schi{\o}tz, {P O}",

year = "1991",

month = may,

doi = "10.1007/BF01993128",

language = "English",

volume = "33",

pages = "64--6",

journal = "Agents and Actions",

issn = "0065-4299",

publisher = "Birkhauser Verlag Basel",

number = "1-2",

}

TY - JOUR

T1 - Comparison of histamine release in cord blood and adult blood

AU - Nielsen, B W

AU - Engberg, T M

AU - Bjerke, T

AU - Schiøtz, P O

PY - 1991/5

Y1 - 1991/5

N2 - Histamine release (HR) after stimulation with anti-IgE, concanavalin A (ConA) and Formyl-Met-Leu-Phe (FMLP) from 97 cord blood samples was compared to results obtained in identically treated blood samples from adults. The maximal HR obtained with anti-IgE did not differ significantly from the values obtained in adult blood, although a ten times higher concentration of anti-IgE was required for maximum release. Passive sensitization with IgE-rich plasma caused a significant increase in maximal anti-IgE-induced HR in the majority of cord blood samples, and the dose-response curve was similar to that obtained in adult blood. Challenge with ConA and FMLP caused a HR similar to that seen in adult blood, but the close correlation between anti-IgE- and concanavalin A-induced HR seen in adult blood was absent in cord blood.

AB - Histamine release (HR) after stimulation with anti-IgE, concanavalin A (ConA) and Formyl-Met-Leu-Phe (FMLP) from 97 cord blood samples was compared to results obtained in identically treated blood samples from adults. The maximal HR obtained with anti-IgE did not differ significantly from the values obtained in adult blood, although a ten times higher concentration of anti-IgE was required for maximum release. Passive sensitization with IgE-rich plasma caused a significant increase in maximal anti-IgE-induced HR in the majority of cord blood samples, and the dose-response curve was similar to that obtained in adult blood. Challenge with ConA and FMLP caused a HR similar to that seen in adult blood, but the close correlation between anti-IgE- and concanavalin A-induced HR seen in adult blood was absent in cord blood.

KW - Aging/blood

KW - Antibodies, Anti-Idiotypic/pharmacology

KW - Basophils/drug effects

KW - Concanavalin A/pharmacology

KW - Fetal Blood/metabolism

KW - Histamine/blood

KW - Histamine Release/drug effects

KW - Immunoglobulin E/immunology

KW - N-Formylmethionine Leucyl-Phenylalanine/pharmacology

U2 - 10.1007/BF01993128

DO - 10.1007/BF01993128

M3 - Journal article

C2 - 1716839

VL - 33

SP - 64

EP - 66

JO - Agents and Actions

JF - Agents and Actions

SN - 0065-4299

IS - 1-2

ER -

Comparison of histamine release in cord blood and adult blood

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