Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital

Comparison of four MRI protocols for detection of extrahepatic colorectal cancer metastases

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


  1. Tractography reproducibility challenge with empirical data (TraCED): The 2017 ISMRM diffusion study group challenge

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Brain capillary transit time heterogeneity in healthy volunteers measured by dynamic contrast-enhanced T1 -weighted perfusion MRI

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Comparison of global cerebral blood flow measured by phase-contrast mapping MRI with (15) O-H2 O positron emission tomography

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. How to Manage (Treat) Immediate-type Adverse Reactions to GBCA

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

PURPOSE: To compare three magnetic resonance imaging (MRI) protocols containing diffusion-weighted imaging with background suppression (DWIBS) and one traditional protocol for detecting extrahepatic colorectal cancer metastases.

MATERIALS AND METHODS: Thirty patients with extrahepatic colorectal cancer metastases were scanned in three stations from the skull base to the upper thighs using a 1.5T MRI system with six different MRI sequences; transverse and coronal T2 -weighted (T2 W) turbo spin-echo (TSE), coronal short tau inversion recovery (STIR), 3D T1 W TSE, DWIBS, and a contrast-enhanced T1 W 3D gradient echo (GRE) sequence. The six sequences were used to build four hypothetical MRI interpretive sets which were read by two readers in consensus, blinded to prior imaging. Lesions were categorized into 13 anatomic regions. Fluorodeoxyglucose / positron emission tomography / computed tomography (FDG-PET/CT) read with full access to prior imaging and clinical records was used as the reference standard. Sensitivity, specificity, and false discovery rate (FDR) were calculated as appropriate and receiver operating characteristic (ROC) curves were constructed.

RESULTS: In all, 177 malignant lesions were detected by FDG-PET/CT and distributed in 92 out of 390 scanned anatomic regions. The sensitivity was statistically higher in two out of three sets incorporating DWIBS on a per-lesion basis (66.7%, 63.3%, and 66.7% vs. 57.6%) (P = 0.01, P = 0.11, and P = 0.01, respectively) and in all sets incorporating DWIBS on a per-region basis (75.0%, 75.0%, and 77.2 vs. 66.3%) (P = 0.04, P = 0.04, and P = 0.01, respectively). There was no difference in specificity, FDR, or AUCROC . There was no difference between sets containing DWIBS irrespective of the use of a contrast-enhanced sequence.

CONCLUSION: MRI sets containing DWIBS had superior sensitivity. This sensitivity was retained when omitting a contrast-enhanced sequence.

LEVEL OF EVIDENCE: 1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2017;46:1619-1630.

TidsskriftJournal of magnetic resonance imaging : JMRI
Udgave nummer6
Sider (fra-til)1619-1630
Antal sider12
StatusUdgivet - dec. 2017

Bibliografisk note

© 2017 International Society for Magnetic Resonance in Medicine.

ID: 59376077